NP_001278894.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,007 Da
NCBI Official Full Name
wiskott-Aldrich syndrome protein family member 3 isoform 2
NCBI Official Synonym Full Names
WAS protein family, member 3
NCBI Protein Information
wiskott-Aldrich syndrome protein family member 3
UniProt Protein Name
Wiskott-Aldrich syndrome protein family member 3
UniProt Synonym Protein Names
Protein WAVE-3; Verprolin homology domain-containing protein 3
UniProt Synonym Gene Names
UniProt Entry Name
WASF3_HUMAN
NCBI Summary for WASF3
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]
UniProt Comments for WASF3
WASF3: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: cytoskeleton; lamellipodium; cytoplasm
Molecular Function: actin binding
Biological Process: lamellipodium biogenesis; positive regulation of myelination; regulation of cell shape; actin filament polymerization; protein complex assembly; cytoskeleton organization and biogenesis; oligodendrocyte development
Research Articles on WASF3
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Products associated with WASF3 sirna
Pathways associated with WASF3 sirna
Diseases associated with WASF3 sirna
Organs/Tissues associated with WASF3 sirna
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