NP_998730.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,588 Da
NCBI Official Full Name
zinc finger protein 57
NCBI Official Synonym Full Names
zinc finger protein 57
NCBI Protein Information
zinc finger protein 57
UniProt Protein Name
Zinc finger protein 57
UniProt Synonym Gene Names
UniProt Entry Name
ZFP57_RAT
NCBI Summary for ZFP57
has transcriptional repressor activity in Schwann cells; may play a role in early stages of Schwann cell development [RGD, Feb 2006]
UniProt Comments for ZFP57
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element ().
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Products associated with ZFP57 sirna
Diseases associated with ZFP57 sirna
Organs/Tissues associated with ZFP57 sirna
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