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CP protein :: Ceruloplasmin Protein

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Catalog # MBS173049
Unit / Price DISCONTINUED
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CP protein
Product Name

Ceruloplasmin (CP), Protein

Full Product Name

Ceruloplasmin, Rat Serum

Product Synonym Names
Ceruloplasmin (Cp), Rat
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 604290
Form/Format
Liquid
Concentration
Protein Concentration: Typically >0.5 mg/mL (lot specific)
Source
Rat Serum
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of CP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CP protein
Bulk quantities of Rat Ceruloplasmin available in 10-100 mg lot sizes.

Custom preparations, technical support, bulk quantities and aliquoting available.

Rat Ceruloplasmin is an approximately 120 kDa monomeric serum protein that fuctions as a copper transporter. It is a positive acute phase reactant, the levels of which increase significantly in rats in response to inflammation, tissue injury and disease.
NCBI/Uniprot data below describe general gene information for CP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
122,205 Da[Similar Products]
NCBI Official Full Name
ceruloplasmin, partial
NCBI Official Synonym Full Names
ceruloplasmin (ferroxidase)
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
ceruloplasmin
UniProt Protein Name
Ceruloplasmin
UniProt Synonym Protein Names
Ferroxidase
Protein Family
UniProt Gene Name
UniProt Entry Name
CERU_HUMAN
NCBI Summary for CP
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for CP
CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family.

Protein type: Secreted, signal peptide; Secreted; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase

Chromosomal Location of Human Ortholog: 3q23-q25

Cellular Component: extracellular space; lysosomal membrane; extracellular region

Molecular Function: ferroxidase activity; copper ion binding; chaperone binding

Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport

Disease: Aceruloplasminemia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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