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A disintegrin and metalloproteinase with thrombospondin motifs

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Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity (By similarity). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (By similarity).

Below are the list of possible A disintegrin and metalloproteinase with thrombospondin motifs products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

A disintegrin and metalloproteinase with thrombospondin motifs 1

 A disintegrin and metalloproteinase with thrombospondin motifs 1 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 1 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 1 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1).
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in fol
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licular rupture.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Cellular Component: basement membrane; cytoplasm; cytoplasmic vesicle; extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; metalloendopeptidase activity; protein binding

Biological Process: kidney development; negative regulation of angiogenesis; ovulation from ovarian follicle
 Adamts1 ELISA Kit
 Adamts1 Recombinant
 Adamts1 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 10

 A disintegrin and metalloproteinase with thrombospondin motifs 10 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 10 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 10 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10).
ADAMTS10: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1). WMS1
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is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Cellular Component: extracellular matrix; microfibril
 Adamts10 ELISA Kit
 Adamts10 Recombinant
 Adamts10 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 12

 A disintegrin and metalloproteinase with thrombospondin motifs 12 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 12 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 12 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12).
ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/
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chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: extracellular matrix

Molecular Function: metalloendopeptidase activity; protein binding

Biological Process: cell migration; cell-matrix adhesion; negative regulation of chondrocyte differentiation; proteoglycan catabolic process; proteolysis involved in cellular protein catabolic process; regulation of inflammatory response
 ADAMTS12 ELISA Kit
 ADAMTS12 Recombinant
 ADAMTS12 Antibody
 UNQ1918/PRO4389 ELISA Kit
 UNQ1918/PRO4389 Recombinant
 UNQ1918/PRO4389 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 13

 A disintegrin and metalloproteinase with thrombospondin motifs 13 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 13 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 13 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease).
ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms o
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f the human protein are produced by alternative splicing.

Protein type: Calcium-binding; EC 3.4.24.87; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: endoplasmic reticulum lumen; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; integrin binding; metallopeptidase activity; protein binding; zinc ion binding

Biological Process: peptide catabolic process; protein processing; proteolysis

Disease: Thrombotic Thrombocytopenic Purpura, Congenital
 ADAMTS13 ELISA Kit
 ADAMTS13 Recombinant
 ADAMTS13 Antibody
 C9orf8 ELISA Kit
 C9orf8 Recombinant
 C9orf8 Antibody
 UNQ6102/PRO20085 ELISA Kit
 UNQ6102/PRO20085 Recombinant
 UNQ6102/PRO20085 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 14

 A disintegrin and metalloproteinase with thrombospondin motifs 14 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 14 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 14 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14).
ADAMTS14: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. 4 isoforms of the human protein are produced by alternative promote
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r.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: extracellular region

Molecular Function: metalloendopeptidase activity
 ADAMTS14 ELISA Kit
 ADAMTS14 Recombinant
 ADAMTS14 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 15

 A disintegrin and metalloproteinase with thrombospondin motifs 15 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 15 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 15 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15).
ADAMTS15:

Protein type: EC 3.4.24.-; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q25
 ADAMTS15 ELISA Kit
 ADAMTS15 Recombinant
 ADAMTS15 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 16

 A disintegrin and metalloproteinase with thrombospondin motifs 16 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 16 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 16 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16).
ADAMTS16: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Biological Process: regulation of systemic arterial blood pressure; ureteric bud br
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anching
 Adamts16 ELISA Kit
 Adamts16 Recombinant
 Adamts16 Antibody
 Kiaa2029 ELISA Kit
 Kiaa2029 Recombinant
 Kiaa2029 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 17

 A disintegrin and metalloproteinase with thrombospondin motifs 17 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 17 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 17 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17).
ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the cha
>>>
racteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q24

Disease: Weill-marchesani-like Syndrome
 ADAMTS17 ELISA Kit
 ADAMTS17 Recombinant
 ADAMTS17 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 18

 A disintegrin and metalloproteinase with thrombospondin motifs 18 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 18 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 18 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18).
ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital sk
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ull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q23

Biological Process: eye development

Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus
 ADAMTS18 ELISA Kit
 ADAMTS18 Recombinant
 ADAMTS18 Antibody
 ADAMTS21 ELISA Kit
 ADAMTS21 Recombinant
 ADAMTS21 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 19

 A disintegrin and metalloproteinase with thrombospondin motifs 19 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 19 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 19 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19).
ADAMTS19:

Protein type: EC 3.4.24.-; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q23.3
 ADAMTS19 ELISA Kit
 ADAMTS19 Recombinant
 ADAMTS19 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 2

 A disintegrin and metalloproteinase with thrombospondin motifs 2 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 2 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 2 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI).
ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in developme
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nt that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.14; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Cellular Component: proteinaceous extracellular matrix

Molecular Function: peptidase activity

Biological Process: collagen fibril organization; lung development; protein processing; skin development; spermatogenesis
 Adamts2 ELISA Kit
 Adamts2 Recombinant
 Adamts2 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 20

 A disintegrin and metalloproteinase with thrombospondin motifs 20 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 20 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 20 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20).
ADAMTS20: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secre
>>>
ted, signal peptide

Cellular Component: extracellular space

Molecular Function: endopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix organization and biogenesis; negative regulation of apoptosis; positive regulation of melanocyte differentiation; positive regulation of signal transduction; proteolysis; regulation of pigmentation during development
 Adamts20 ELISA Kit
 Adamts20 Recombinant
 Adamts20 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 3

 A disintegrin and metalloproteinase with thrombospondin motifs 3 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 3 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 3 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme).
ADAMTS3: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Prot
>>>
ease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: endopeptidase activity; metalloendopeptidase activity; protein binding

Biological Process: collagen biosynthetic process; collagen fibril organization; fibril organization and biogenesis; protein processing
 ADAMTS3 ELISA Kit
 ADAMTS3 Recombinant
 ADAMTS3 Antibody
 KIAA0366 ELISA Kit
 KIAA0366 Recombinant
 KIAA0366 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 4

 A disintegrin and metalloproteinase with thrombospondin motifs 4 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 4 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 4 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (ADMP-1) (Aggrecanase-1).
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
 ADAMTS4 ELISA Kit
 ADAMTS4 Recombinant
 ADAMTS4 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 5

 A disintegrin and metalloproteinase with thrombospondin motifs 5 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 5 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 5 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2).
ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Protein type: EC 3.4.24.-; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Se
>>>
creted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: endoplasmic reticulum lumen; extracellular region

Molecular Function: integrin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding

Biological Process: extracellular matrix disassembly
 ADAMTS5 ELISA Kit
 ADAMTS5 Recombinant
 ADAMTS5 Antibody
 ADAMTS11 ELISA Kit
 ADAMTS11 Recombinant
 ADAMTS11 Antibody
 ADMP2 ELISA Kit
 ADMP2 Recombinant
 ADMP2 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 6

 A disintegrin and metalloproteinase with thrombospondin motifs 6 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 6 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 6 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6).
ADAMTS6: a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin t
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ype 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q12

Molecular Function: metallopeptidase activity
 ADAMTS6 ELISA Kit
 ADAMTS6 Recombinant
 ADAMTS6 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 7

 A disintegrin and metalloproteinase with thrombospondin motifs 7 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 7 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 7 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (COMPase).
ADAMTS7: Metalloprotease that may play a role in the degradation of COMP.

Protein type: Cell surface; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Compo
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nent: endoplasmic reticulum lumen

Molecular Function: metalloendopeptidase activity; metallopeptidase activity; protein binding

Biological Process: negative regulation of chondrocyte differentiation; proteolysis involved in cellular protein catabolic process
 ADAMTS7 ELISA Kit
 ADAMTS7 Recombinant
 ADAMTS7 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 8

 A disintegrin and metalloproteinase with thrombospondin motifs 8 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 8 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 8 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (METH-2).
ADAMTS8: Has anti-angiogenic properties.

Protein type: Cell cycle regulation; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
 Adamts8 ELISA Kit
 Adamts8 Recombinant
 Adamts8 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs 9

 A disintegrin and metalloproteinase with thrombospondin motifs 9 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs 9 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs 9 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9).
ADAMTS9: Cleaves the large aggregating proteoglycans, aggrecan and versican. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
>>>
r>Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: metallopeptidase activity

Biological Process: glycoprotein catabolic process; multicellular organismal development; proteolysis
 ADAMTS9 ELISA Kit
 ADAMTS9 Recombinant
 ADAMTS9 Antibody
 KIAA1312 ELISA Kit
 KIAA1312 Recombinant
 KIAA1312 Antibody
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A disintegrin and metalloproteinase with thrombospondin motifs gon-1

 A disintegrin and metalloproteinase with thrombospondin motifs gon-1 ELISA Kit
 A disintegrin and metalloproteinase with thrombospondin motifs gon-1 Recombinant
 A disintegrin and metalloproteinase with thrombospondin motifs gon-1 Antibody
Also known as A disintegrin and metalloproteinase with thrombospondin motifs gon-1 (ADAMTS gon-1) (Abnormal gonad development protein 1).
Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Has a protease-independent fun
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ction in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
 gon-1 ELISA Kit
 gon-1 Recombinant
 gon-1 Antibody
 F25H8.3 ELISA Kit
 F25H8.3 Recombinant
 F25H8.3 Antibody
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Proteins Root Name Listing
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