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Abl interactor

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May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.

Below are the list of possible Abl interactor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Abl interactor 1

 Abl interactor 1 ELISA Kit
 Abl interactor 1 Recombinant
 Abl interactor 1 Antibody
Also known as Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1).
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein
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complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
 ABI1 ELISA Kit
 ABI1 Recombinant
 ABI1 Antibody
 SSH3BP1 ELISA Kit
 SSH3BP1 Recombinant
 SSH3BP1 Antibody
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Abl interactor 2

 Abl interactor 2 ELISA Kit
 Abl interactor 2 Recombinant
 Abl interactor 2 Antibody
Also known as Abl interactor 2 (Abelson interactor 2) (Abi-2).
Abi-2: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphor
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ylation of MENA. Belongs to the ABI family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: cell-cell adherens junction; cytosol; dendrite; filopodium; lamellipodium

Molecular Function: protein complex binding; Rac GTPase binding; SH3 domain binding; ubiquitin protein ligase binding

Biological Process: camera-type eye development; cell migration; cell motility; dendrite development; learning and/or memory; peptidyl-tyrosine phosphorylation; Rac protein signal transduction
 Abi2 ELISA Kit
 Abi2 Recombinant
 Abi2 Antibody
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Abl interactor homolog

 Abl interactor homolog ELISA Kit
 Abl interactor homolog Recombinant
 Abl interactor homolog Antibody
Involved in regulation of actin and microtubule organization. Required for proper cytokinesis.
 abiA ELISA Kit
 abiA Recombinant
 abiA Antibody
 DDB_G0267956 ELISA Kit
 DDB_G0267956 Recombinant
 DDB_G0267956 Antibody
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