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Abscission/NoCut checkpoint regulator

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Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Below are the list of possible Abscission/NoCut checkpoint regulator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Abscission/NoCut checkpoint regulator

 Abscission/NoCut checkpoint regulator ELISA Kit
 Abscission/NoCut checkpoint regulator Recombinant
 Abscission/NoCut checkpoint regulator Antibody
Also known as Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19).
ZFYVE19: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: centrosome; cleavage furrow; midbody

Molecular Function: phosphatidylinositol 3-phosphate binding; protein
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binding

Biological Process: abscission; negative regulation of cytokinesis
 ZFYVE19 ELISA Kit
 ZFYVE19 Recombinant
 ZFYVE19 Antibody
 ANCHR ELISA Kit
 ANCHR Recombinant
 ANCHR Antibody
 MPFYVE ELISA Kit
 MPFYVE Recombinant
 MPFYVE Antibody
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