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Actin cross-linking toxin

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Actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding .

Below are the list of possible Actin cross-linking toxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Actin cross-linking toxin VgrG1

 Actin cross-linking toxin VgrG1 ELISA Kit
 Actin cross-linking toxin VgrG1 Recombinant
 Actin cross-linking toxin VgrG1 Antibody
Actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:17873062, PubMed:20150509). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-d
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ependent and independent manners (). Acts as an acid--amino-acid ligase that transfers the gamma-phosphoryl group of ATP to the 'Glu-270' actin residue, resulting in the formation of an activated acyl phosphate intermediate. This intermediate is further hydrolyzed and the energy of hydrolysis is utilized for the formation of the amide bond between actin subunits ().
 vgrG1 ELISA Kit
 vgrG1 Recombinant
 vgrG1 Antibody
 vgrG-1 ELISA Kit
 vgrG-1 Recombinant
 vgrG-1 Antibody
 VC_1416 ELISA Kit
 VC_1416 Recombinant
 VC_1416 Antibody
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