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Activating signal cointegrator 1 complex

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Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

Below are the list of possible Activating signal cointegrator 1 complex products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Activating signal cointegrator 1 complex subunit 1

 Activating signal cointegrator 1 complex subunit 1 ELISA Kit
 Activating signal cointegrator 1 complex subunit 1 Recombinant
 Activating signal cointegrator 1 complex subunit 1 Antibody
Also known as Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).
ASCC1: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. Defects in ASCC1 may be a cause of Barrett esophagus (BE). A condition characterized by a m
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etaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in ASCC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10pter-q25.3

Cellular Component: neuromuscular junction; nucleoplasm; nucleus; transcription factor complex

Molecular Function: protein binding

Biological Process: DNA dealkylation; regulation of transcription, DNA-dependent

Disease: Barrett Esophagus; Spinal Muscular Atrophy With Congenital Bone Fractures 2
 ASCC1 ELISA Kit
 ASCC1 Recombinant
 ASCC1 Antibody
 CGI-18 ELISA Kit
 CGI-18 Recombinant
 CGI-18 Antibody
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Activating signal cointegrator 1 complex subunit 2

 Activating signal cointegrator 1 complex subunit 2 ELISA Kit
 Activating signal cointegrator 1 complex subunit 2 Recombinant
 Activating signal cointegrator 1 complex subunit 2 Antibody
Also known as Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100).
ASCC2: Enhances NF-kappa-B, SRF and AP1 transactivation. Belongs to the ASCC2 family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: nucleus

Biological Process: regulation of transcription, DNA-dependent
 Ascc2 ELISA Kit
 Ascc2 Recombinant
 Ascc2 Antibody
 Asc1p100 ELISA Kit
 Asc1p100 Recombinant
 Asc1p100 Antibody
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Activating signal cointegrator 1 complex subunit 2 homolog

 Activating signal cointegrator 1 complex subunit 2 homolog ELISA Kit
 Activating signal cointegrator 1 complex subunit 2 homolog Recombinant
 Activating signal cointegrator 1 complex subunit 2 homolog Antibody
Enhances NF-kappa-B, SRF and AP1 transactivation.
 ascc2 ELISA Kit
 ascc2 Recombinant
 ascc2 Antibody
 DDB_G0280455 ELISA Kit
 DDB_G0280455 Recombinant
 DDB_G0280455 Antibody
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Activating signal cointegrator 1 complex subunit 3

 Activating signal cointegrator 1 complex subunit 3 ELISA Kit
 Activating signal cointegrator 1 complex subunit 3 Recombinant
 Activating signal cointegrator 1 complex subunit 3 Antibody
ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.

Pro
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tein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; Golgi apparatus; intracellular; membrane; nucleus

Molecular Function: ATP-dependent 3'-5' DNA helicase activity

Biological Process: cell proliferation; DNA dealkylation; DNA duplex unwinding
 Ascc3 ELISA Kit
 Ascc3 Recombinant
 Ascc3 Antibody
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Activating signal cointegrator 1 complex subunit 3-like

 Activating signal cointegrator 1 complex subunit 3-like ELISA Kit
 Activating signal cointegrator 1 complex subunit 3-like Recombinant
 Activating signal cointegrator 1 complex subunit 3-like Antibody
 ascc3l ELISA Kit
 ascc3l Recombinant
 ascc3l Antibody
 DDB_G0270042 ELISA Kit
 DDB_G0270042 Recombinant
 DDB_G0270042 Antibody
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