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Activin receptor

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On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

Below are the list of possible Activin receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Activin receptor type-1

 Activin receptor type-1 ELISA Kit
 Activin receptor type-1 Recombinant
 Activin receptor type-1 Antibody
Also known as Activin receptor type-1 (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I).
ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I re
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ceptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: activin receptor complex; integral to plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding

Biological Process: activin receptor signaling pathway; BMP signaling pathway; G1/S transition of mitotic cell cycle; negative regulation of activin receptor signaling pathway; negative regulation of signal transduction; peptidyl-threonine phosphorylation; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of ossification; transforming growth factor beta receptor signaling pathway

Disease: Fibrodysplasia Ossificans Progressiva
 ACVR1 ELISA Kit
 ACVR1 Recombinant
 ACVR1 Antibody
 ACVRLK2 ELISA Kit
 ACVRLK2 Recombinant
 ACVRLK2 Antibody
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Activin receptor type-1B

 Activin receptor type-1B ELISA Kit
 Activin receptor type-1B Recombinant
 Activin receptor type-1B Antibody
Also known as Activin receptor type-1B (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2).
ALK4: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary glan
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d, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. ACVRIB is abundantly expressed in systemic sclerosis patient fibroblasts and production of collagen is also induced by activin-A/INHBA. This suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Cellular Component: activin receptor complex; cell surface; integral to plasma membrane; receptor complex

Molecular Function: activin binding; activin receptor activity; activin receptor activity, type I; ATP binding; growth factor binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; central nervous system development; development of primary female sexual characteristics; G1/S transition of mitotic cell cycle; hair follicle development; in utero embryonic development; negative regulation of cell growth; peptidyl-threonine phosphorylation; positive regulation of activin receptor signaling pathway; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of signal transduction; regulation of transcription, DNA-dependent; signal transduction
 Acvr1b ELISA Kit
 Acvr1b Recombinant
 Acvr1b Antibody
 Acvrlk4 ELISA Kit
 Acvrlk4 Recombinant
 Acvrlk4 Antibody
 Alk4 ELISA Kit
 Alk4 Recombinant
 Alk4 Antibody
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Activin receptor type-1C

 Activin receptor type-1C ELISA Kit
 Activin receptor type-1C Recombinant
 Activin receptor type-1C Antibody
Also known as Activin receptor type-1C (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).
ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then b
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ind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Cellular Component: activin receptor complex; cell surface; cytoplasm; plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; growth factor binding; protein serine/threonine kinase activity; SMAD binding

Biological Process: apoptotic nuclear changes; cell differentiation; determination of left/right symmetry; in utero embryonic development; negative regulation of insulin secretion; positive regulation of apoptosis; positive regulation of caspase activity; protein amino acid phosphorylation; regulation of apoptosis; response to dietary excess; response to glucose stimulus; response to insulin stimulus; sequestering of lipid; transforming growth factor beta receptor complex assembly; trophectodermal cell proliferation
 Acvr1c ELISA Kit
 Acvr1c Recombinant
 Acvr1c Antibody
 Alk7 ELISA Kit
 Alk7 Recombinant
 Alk7 Antibody
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Activin receptor type-2A

 Activin receptor type-2A ELISA Kit
 Activin receptor type-2A Recombinant
 Activin receptor type-2A Antibody
Also known as Activin receptor type-2A (Activin receptor type IIA) (ACTR-IIA).
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
 ACVR2A ELISA Kit
 ACVR2A Recombinant
 ACVR2A Antibody
 ACTRII ELISA Kit
 ACTRII Recombinant
 ACTRII Antibody
 ACVR2 ELISA Kit
 ACVR2 Recombinant
 ACVR2 Antibody
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Activin receptor type-2B

 Activin receptor type-2B ELISA Kit
 Activin receptor type-2B Recombinant
 Activin receptor type-2B Antibody
Also known as Activin receptor type-2B (Activin receptor type IIB) (ACTR-IIB).
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes i
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ncluding neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor ().
 ACVR2B ELISA Kit
 ACVR2B Recombinant
 ACVR2B Antibody
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