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Acylglycerol kinase

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Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.

Below are the list of possible Acylglycerol kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Acylglycerol kinase

 Acylglycerol kinase ELISA Kit
 Acylglycerol kinase Recombinant
 Acylglycerol kinase Antibody
Also known as Acylglycerol kinase, mitochondrial (Multiple substrate lipid kinase) (MuLK) (Multi-substrate lipid kinase).
AGK: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in trans
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activation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. Defects in AGK are the cause of mitochondrial DNA depletion syndrome type 10 (MTDPS10). An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. Defects in AGK are the cause of cataract, congenital, autosomal recessive type 5 (CATC5). CATC5 consists of an opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.107; EC 2.7.1.94; Kinase, lipid; Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis

Cellular Component: intracellular membrane-bound organelle; membrane; mitochondrion

Molecular Function: ceramide kinase activity; lipid kinase activity

Biological Process: ceramide biosynthetic process; lipid phosphorylation
 Agk ELISA Kit
 Agk Recombinant
 Agk Antibody
 Mulk ELISA Kit
 Mulk Recombinant
 Mulk Antibody
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