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Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.

Below are the list of possible Afadin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Afadin ELISA Kit
 Afadin Recombinant
 Afadin Antibody
Also known as Afadin (Afadin adherens junction formation factor) (Protein Af-6).
Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal se
quences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein

Cellular Component: adherens junction; apical junction complex; apical part of cell; cell junction; cell-cell adherens junction; cytoplasm; intercellular junction; nucleoplasm; plasma membrane

Molecular Function: cell adhesion molecule binding; LIM domain binding; protein binding; Ras GTPase binding

Biological Process: brain morphogenesis; cerebral cortex development; homeostasis of number of cells; positive regulation of GTPase activity; radial glial cell differentiation; telencephalon development
 Afdn ELISA Kit
 Afdn Recombinant
 Afdn Antibody
 Af6 ELISA Kit
 Af6 Recombinant
 Af6 Antibody
 Mllt4 ELISA Kit
 Mllt4 Recombinant
 Mllt4 Antibody
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