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Agouti-signaling protein

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Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.

Below are the list of possible Agouti-signaling protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Agouti-signaling protein

 Agouti-signaling protein ELISA Kit
 Agouti-signaling protein Recombinant
 Agouti-signaling protein Antibody
Also known as Agouti-signaling protein (ASP) (Agouti coat color protein) (Agouti switch protein).
ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In highe
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r primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Protein type: Secreted; Secreted, signal peptide

Molecular Function: melanocortin receptor binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding

Biological Process: adult feeding behavior; generation of precursor metabolites and energy; melanin biosynthetic process; melanosome organization and biogenesis; melanosome transport; pigmentation; positive regulation of melanin biosynthetic process; regulation of molecular function, epigenetic
 Asip ELISA Kit
 Asip Recombinant
 Asip Antibody
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