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Alpha-mammal toxin

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Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.

Below are the list of possible Alpha-mammal toxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Alpha-mammal toxin AaH2

 Alpha-mammal toxin AaH2 ELISA Kit
 Alpha-mammal toxin AaH2 Recombinant
 Alpha-mammal toxin AaH2 Antibody
Also known as Alpha-mammal toxin AaH2 (AaH II) (AaHII) (Neurotoxin 2).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated chann
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els, thereby blocking neuronal transmission. This toxin is active against mammals.
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Alpha-mammal toxin Aah3

 Alpha-mammal toxin Aah3 ELISA Kit
 Alpha-mammal toxin Aah3 Recombinant
 Alpha-mammal toxin Aah3 Antibody
Also known as Alpha-mammal toxin Aah3 (AaH III) (AaHIII) (Neurotoxin 3) (Neurotoxin III).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of
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the activated channels, thereby blocking neuronal transmission.
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Alpha-mammal toxin BeM9

 Alpha-mammal toxin BeM9 ELISA Kit
 Alpha-mammal toxin BeM9 Recombinant
 Alpha-mammal toxin BeM9 Antibody
Also known as Alpha-mammal toxin BeM9 (Neurotoxin M9).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blo
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cking neuronal transmission. Has paralytic activity in mice.
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Alpha-mammal toxin BmK-M8

 Alpha-mammal toxin BmK-M8 ELISA Kit
 Alpha-mammal toxin BmK-M8 Recombinant
 Alpha-mammal toxin BmK-M8 Antibody
Also known as Alpha-mammal toxin BmK-M8 (BmK8) (Bmk M8) (BmK-VIII) (BmKVIII).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activate
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d channels, thereby blocking neuronal transmission. This acidic toxin has a weak toxicity and is active against mammals.
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Alpha-mammal toxin Bot3

 Alpha-mammal toxin Bot3 ELISA Kit
 Alpha-mammal toxin Bot3 Recombinant
 Alpha-mammal toxin Bot3 Antibody
Also known as Alpha-mammal toxin Bot3 (Bot III) (BotIII) (Neurotoxin III).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated c
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hannels, thereby blocking neuronal transmission. Is active against mammals and binds with high affinity to rat brain synaptosomes.
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Alpha-mammal toxin Lqh2

 Alpha-mammal toxin Lqh2 ELISA Kit
 Alpha-mammal toxin Lqh2 Recombinant
 Alpha-mammal toxin Lqh2 Antibody
Also known as Alpha-mammal toxin Lqh2 (Lqh II) (LqhII).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby bl
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ocking neuronal transmission. The dissociation is voltage-dependent. Is active on mammals and competes for alpha-toxins binding on both mammalian and cockroach sodium channels.
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Alpha-mammal toxin Lqq5

 Alpha-mammal toxin Lqq5 ELISA Kit
 Alpha-mammal toxin Lqq5 Recombinant
 Alpha-mammal toxin Lqq5 Antibody
Also known as Alpha-mammal toxin Lqq5 (Lqq V) (Neurotoxin V).
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, ther
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eby blocking neuronal transmission. Is active on mammals and bind with high affinity to rat brain synaptosome. Does not display phospholipid-binding activity.
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Alpha-mammal toxin Ts2

 Alpha-mammal toxin Ts2 ELISA Kit
 Alpha-mammal toxin Ts2 Recombinant
 Alpha-mammal toxin Ts2 Antibody
Also known as Alpha-mammal toxin Ts2 (P-Mice-beta* NaTx5.1) (Tityustoxin II) (Toxin II) (TsTX-II) (Tst2) (Toxin T1-IV) (TsTX III-8) (TsTX-III).
Alpha toxins bind voltage-independently at site-3 of
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sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.5/SCN5A, Nav1.6/SCN8A and Nav1.7/SCN9A voltage-gated sodium channels, with the highest affinity for Nav1.3/SCN3A, followed by Nav1.6/SCN8A and Nav1.7/SCN9A which are affected almost equally. Interestingly, shows a significant shift of the voltage dependence of activation for Nav1.3/SCN3A that is characteristic of beta-toxins (PubMed:21549737). In addition, in presence of LPS, this toxin inhibits the release of NO, IL-6 and TNF-alpha in J774.1 cells (PubMed:21549737). Further, in the absence of LPS, it stimulates the production of the anti-inflammatory cytokine IL-10 (PubMed:21549737, PubMed:23085190). This toxin is active on mammals.
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Proteins Root Name Listing
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