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May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).

Below are the list of possible Alsin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Alsin ELISA Kit
 Alsin Recombinant
 Alsin Antibody
Also known as Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein).
ALS2: May act as a GTPase regulator. Controls survival and growth of spinal motoneurons. Defects in ALS2 are the cause of amyotrophic lateral sclerosis type 2 (ALS2). ALS2 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is lik
ely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms. Defects in ALS2 are the cause of juvenile primary lateral sclerosis (JPLS). JPLS is a neurodegenerative disorder which is closely related to but clinically distinct from amyotrophic lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the upper motor neurons of the motor cortex while the lower neurons are unaffected. Defects in ALS2 are the cause of infantile-onset ascending spastic paralysis (IAHSP). IAHSP is characterized by progressive spasticity and weakness of limbs. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: centrosome; cytosol; dendrite; early endosome; growth cone; lamellipodium; protein complex; ruffle; vesicle

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activator activity; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity

Biological Process: endosome organization and biogenesis; neurite morphogenesis; positive regulation of GTPase activity; positive regulation of protein kinase activity; positive regulation of Rac protein signal transduction; regulation of endosome size

Disease: Amyotrophic Lateral Sclerosis 2, Juvenile; Primary Lateral Sclerosis, Juvenile; Spastic Paralysis, Infantile-onset Ascending
 ALS2 Recombinant
 ALS2 Antibody
 ALS2CR6 Recombinant
 ALS2CR6 Antibody
 KIAA1563 Recombinant
 KIAA1563 Antibody
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Alsin homolog

 Alsin homolog ELISA Kit
 Alsin homolog Recombinant
 Alsin homolog Antibody
Also known as Alsin homolog (Amyotrophic lateral sclerosis 2 protein homolog).
Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab5 into its active GTP-bound form.
 Als2 ELISA Kit
 Als2 Recombinant
 Als2 Antibody
 CG7158 ELISA Kit
 CG7158 Recombinant
 CG7158 Antibody
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