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Antigen peptide transporter

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Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).

Below are the list of possible Antigen peptide transporter products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Antigen peptide transporter 1

 Antigen peptide transporter 1 ELISA Kit
 Antigen peptide transporter 1 Recombinant
 Antigen peptide transporter 1 Antibody
Also known as Antigen peptide transporter 1 (APT1) (ATP-binding cassette sub-family B member 2) (Histocompatibility antigen modifier 1) (Peptide transporter TAP1).
TAP1: a 'transporter associated with antigen processing' (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding s
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ite of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Defects in TAP1 are a cause of bare lymphocyte syndrome.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter

Cellular Component: integral to endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; membrane; mitochondrion; TAP complex

Molecular Function: ADP binding; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; MHC class I protein binding; nucleotide binding; peptide antigen binding; peptide antigen-transporting ATPase activity; peptide transporter activity; protein heterodimerization activity; protein homodimerization activity; TAP1 binding; TAP2 binding; tapasin binding

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cytosol to ER transport; defense response; intracellular transport of viral proteins in host cell; peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; protection from natural killer cell mediated cytotoxicity; transmembrane transport
 Tap1 ELISA Kit
 Tap1 Recombinant
 Tap1 Antibody
 Abcb2 ELISA Kit
 Abcb2 Recombinant
 Abcb2 Antibody
 Ham-1 ELISA Kit
 Ham-1 Recombinant
 Ham-1 Antibody
 Ham1 ELISA Kit
 Ham1 Recombinant
 Ham1 Antibody
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Antigen peptide transporter 2

 Antigen peptide transporter 2 ELISA Kit
 Antigen peptide transporter 2 Recombinant
 Antigen peptide transporter 2 Antibody
Also known as Antigen peptide transporter 2 (APT2) (ATP-binding cassette sub-family B member 3).
transports peptides into the ER lumen for binding with MHC class I molecules; plays a role in antigen processing and presentation [RGD, Feb 2006]
 Tap2 ELISA Kit
 Tap2 Recombinant
 Tap2 Antibody
 Abcb3 ELISA Kit
 Abcb3 Recombinant
 Abcb3 Antibody
 Mtp2 ELISA Kit
 Mtp2 Recombinant
 Mtp2 Antibody
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