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APC/C activator protein

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Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.

Below are the list of possible APC/C activator protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

APC/C activator protein CDC20

 APC/C activator protein CDC20 ELISA Kit
 APC/C activator protein CDC20 Recombinant
 APC/C activator protein CDC20 Antibody
Also known as APC/C activator protein CDC20 (Cell division control protein 20).
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them
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in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
 CDC20 ELISA Kit
 CDC20 Recombinant
 CDC20 Antibody
 YGL116W ELISA Kit
 YGL116W Recombinant
 YGL116W Antibody
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APC/C activator protein CDH1

 APC/C activator protein CDH1 ELISA Kit
 APC/C activator protein CDH1 Recombinant
 APC/C activator protein CDH1 Antibody
Also known as APC/C activator protein CDH1 (CDC20 homolog 1) (Homolog of CDC twenty 1).
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and su
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bsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.
 CDH1 ELISA Kit
 CDH1 Recombinant
 CDH1 Antibody
 HCT1 ELISA Kit
 HCT1 Recombinant
 HCT1 Antibody
 YGL003C ELISA Kit
 YGL003C Recombinant
 YGL003C Antibody
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Proteins Root Name Listing
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