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Apoptotic chromatin condensation inducer in the nucleus

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Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity).

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Apoptotic chromatin condensation inducer in the nucleus

 Apoptotic chromatin condensation inducer in the nucleus ELISA Kit
 Apoptotic chromatin condensation inducer in the nucleus Recombinant
 Apoptotic chromatin condensation inducer in the nucleus Antibody
Also known as Apoptotic chromatin condensation inducer in the nucleus (Acinus).
acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex on
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ly transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described.

Protein type: Apoptosis; RNA splicing; RNA-binding; Spliceosome

Cellular Component: cytoplasm; nuclear speck; nucleolus; nucleoplasm; nucleus; plasma membrane

Biological Process: apoptosis; apoptotic chromosome condensation; negative regulation of nuclear mRNA splicing, via spliceosome; regulation of apoptosis
 Acin1 ELISA Kit
 Acin1 Recombinant
 Acin1 Antibody
 Acinus ELISA Kit
 Acinus Recombinant
 Acinus Antibody
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