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Apoptotic protease-activating factor

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).

Below are the list of possible Apoptotic protease-activating factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Apoptotic protease-activating factor 1

 Apoptotic protease-activating factor 1 ELISA Kit
 Apoptotic protease-activating factor 1 Recombinant
 Apoptotic protease-activating factor 1 Antibody
Also known as Apoptotic protease-activating factor 1 (APAF-1).
APAF: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Monomer. Oligomerizes upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-
caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain). By E2F and p53/TP53 in apoptotic neurons. Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Cellular Component: apoptosome; cytosol; nucleus

Molecular Function: caspase activator activity; heat shock protein binding; identical protein binding

Biological Process: brain development; caspase activation; caspase activation via cytochrome c; forebrain development; multicellular organismal development; neural tube closure; neuron apoptosis; protein homooligomerization
 Apaf1 ELISA Kit
 Apaf1 Recombinant
 Apaf1 Antibody
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