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ARF GTPase-activating protein

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GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).

Below are the list of possible ARF GTPase-activating protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

ARF GTPase-activating protein GIT1

 ARF GTPase-activating protein GIT1 ELISA Kit
 ARF GTPase-activating protein GIT1 Recombinant
 ARF GTPase-activating protein GIT1 Antibody
Also known as ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1).
GIT1: a multidomain, adaptor protein that regulates cellular processes, such as migration and protrusive activity, by bringing together various signaling molecules, including PIX, PAK,
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and paxillin. Phosphorylation on Ser-709 increases its binding to paxillin and regulates cellular protrusions. Possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Functions as part of a multi-molecular signaling complex that regulates membrane protrusions and cell migration. Regulates PLC-gamma activation by c-Src and integrates signal transduction by G protein coupled receptors (GPCR)s and tyrosine kinase receptors (TKRs).

Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; neuron projection; synapse

Molecular Function: GTPase activator activity; protein binding; protein complex binding; protein homodimerization activity; small GTPase binding

Biological Process: ephrin receptor signaling pathway; formation of immunological synapse; negative regulation of ARF protein signal transduction; regulation of cytokinesis; regulation of G-protein coupled receptor protein signaling pathway
 Git1 ELISA Kit
 Git1 Recombinant
 Git1 Antibody
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ARF GTPase-activating protein GIT2

 ARF GTPase-activating protein GIT2 ELISA Kit
 ARF GTPase-activating protein GIT2 Recombinant
 ARF GTPase-activating protein GIT2 Antibody
Also known as ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2).
GIT2: possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PI
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X exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats.

Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis

Cellular Component: focal adhesion; nucleoplasm

Molecular Function: protein binding; protein complex binding

Biological Process: behavioral response to pain
 Git2 ELISA Kit
 Git2 Recombinant
 Git2 Antibody
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