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ATP-binding cassette sub-family

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cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity).

Below are the list of possible ATP-binding cassette sub-family products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

ATP-binding cassette sub-family A member 1

 ATP-binding cassette sub-family A member 1 ELISA Kit
 ATP-binding cassette sub-family A member 1 Recombinant
 ATP-binding cassette sub-family A member 1 Antibody
Also known as ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1).
ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mic
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e. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle

Cellular Component: cell surface; endocytic vesicle; external side of plasma membrane; Golgi apparatus; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane

Molecular Function: anion transmembrane transporter activity; apolipoprotein A-I binding; apolipoprotein A-I receptor activity; apolipoprotein binding; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; ATPase binding; cholesterol transporter activity; phospholipid transporter activity; protein binding; receptor binding; small GTPase binding; syntaxin binding

Biological Process: aminophospholipid transport; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endosome transport; G-protein coupled receptor protein signaling pathway; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein biosynthetic process; lipoprotein metabolic process; lysosome organization and biogenesis; peptide secretion; phagocytosis, engulfment; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transport; platelet dense granule organization and biogenesis; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; regulation of Cdc42 protein signal transduction; response to high density lipoprotein stimulus; reverse cholesterol transport
 Abca1 ELISA Kit
 Abca1 Recombinant
 Abca1 Antibody
 Abc1 ELISA Kit
 Abc1 Recombinant
 Abc1 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 10

 ATP-binding cassette sub-family A member 10 ELISA Kit
 ATP-binding cassette sub-family A member 10 Recombinant
 ATP-binding cassette sub-family A member 10 Antibody
ABCA10: Probable transporter which may play a role in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCA family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 17q24

Cellular Comp
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onent: intracellular membrane-bound organelle

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: lipid transport
 ABCA10 ELISA Kit
 ABCA10 Recombinant
 ABCA10 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 12

 ATP-binding cassette sub-family A member 12 ELISA Kit
 ATP-binding cassette sub-family A member 12 Recombinant
 ATP-binding cassette sub-family A member 12 Antibody
Also known as ATP-binding cassette sub-family A member 12 (ATP-binding cassette transporter 12) (ATP-binding cassette 12).
ABCA12: Probable transporter involved in lipid homeostasis. ABCA12 mutations are a cause of different subtypes of autosomal recessive congenital ichthyosis (ARCI), including Harlequin ichthyosis (HI), lamellar ichthyosis (LI) and non- bullous congenital ichthyosiform erythr
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oderma (NCIE). HI shows the most severe phenotype. NCIE and LI are clinically characterized by fine, whitish scales on a background of erythematous skin, and large, thick, dark scales over the entire body without serious background erythroderma, respectively. Defects in ABCA12 are the cause of ichthyosis harlequin (HI). A very severe skin disorder in which the neonate is born with a thick covering of armor-like scales. The skin dries out to form hard diamond-shaped plaques separated by fissures, resembling 'armor plating'. The normal facial features are severely affected, with distortion of the lips (eclabion), eyelids (ectropion), ears, and nostrils. Affected babies are often born prematurely and rarely survive the perinatal period. Defects in ABCA12 are the cause of ichthyosis lamellar type 2 (LI2). A non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. It is one the most severe forms of ichthyoses apparent at birth and persisting throughout life. LI patients are born encased in a tight, shiny, translucent covering called collodion membrane. Over the first weeks of life, the collodion membrane is gradually replaced by generalized large, dark brown, plate-like scales with minimal to no erythroderma. Tautness of facial skin commonly results in ectropion, eclabium and scarring alopecia of the scalp. Common complications are severe heat intolerance and recurrent ear infections. Defects in ABCA12 are a cause of erythroderma, ichthyosiform, congenital non-bullous (NCIE). A non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: cytoplasm; plasma membrane

Molecular Function: apolipoprotein A-I receptor binding; ATPase activity, coupled to transmembrane movement of substances; lipid transporter activity; lipid-transporting ATPase activity; protein binding; receptor binding

Biological Process: lipid transport; phospholipid efflux; regulated secretory pathway; secretion by cell; transmembrane transport

Disease: Ichthyosis, Congenital, Autosomal Recessive 4a; Ichthyosis, Congenital, Autosomal Recessive 4b
 ABCA12 ELISA Kit
 ABCA12 Recombinant
 ABCA12 Antibody
 ABC12 ELISA Kit
 ABC12 Recombinant
 ABC12 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 13

 ATP-binding cassette sub-family A member 13 ELISA Kit
 ATP-binding cassette sub-family A member 13 Recombinant
 ATP-binding cassette sub-family A member 13 Antibody
ABCA13: In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to fo
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rm a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009]

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: intracellular membrane-bound organelle

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: cholesterol efflux; phospholipid efflux
 Abca13 ELISA Kit
 Abca13 Recombinant
 Abca13 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 17

 ATP-binding cassette sub-family A member 17 ELISA Kit
 ATP-binding cassette sub-family A member 17 Recombinant
 ATP-binding cassette sub-family A member 17 Antibody
ABCA17: Promotes cholesterol efflux from sperm which renders sperm capable of fertilization. Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols. Belongs to the ABC transporter superfamily. ABCA family.

Cellular Component: intracellular membrane-bound organelle

Molecular Function: ATPas
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e activity, coupled to transmembrane movement of substances

Biological Process: lipid transport
 Abca17 ELISA Kit
 Abca17 Recombinant
 Abca17 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 2

 ATP-binding cassette sub-family A member 2 ELISA Kit
 ATP-binding cassette sub-family A member 2 Recombinant
 ATP-binding cassette sub-family A member 2 Antibody
Also known as ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).
ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.
<
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br>Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: cytoplasmic vesicle; endosome; integral to membrane; lysosomal membrane; lysosome; membrane; microtubule organizing center

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances

Biological Process: cholesterol efflux; cholesterol homeostasis; phospholipid efflux; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to steroid hormone stimulus
 Abca2 ELISA Kit
 Abca2 Recombinant
 Abca2 Antibody
 Abc2 ELISA Kit
 Abc2 Recombinant
 Abc2 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 3

 ATP-binding cassette sub-family A member 3 ELISA Kit
 ATP-binding cassette sub-family A member 3 Recombinant
 ATP-binding cassette sub-family A member 3 Antibody
ABCA3: Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3); also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccu
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lar material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the ABC transporter superfamily. ABCA family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: extracellular space; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: lipid transport; transport
 Abca3 ELISA Kit
 Abca3 Recombinant
 Abca3 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 5

 ATP-binding cassette sub-family A member 5 ELISA Kit
 ATP-binding cassette sub-family A member 5 Recombinant
 ATP-binding cassette sub-family A member 5 Antibody
ABCA5: May play a role in the processing of autolysosomes. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: Golgi apparatus; late endosome; lysosome

Molecular Function: ATP
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ase activity, coupled to transmembrane movement of substances

Biological Process: cholesterol efflux; lipid transport
 Abca5 ELISA Kit
 Abca5 Recombinant
 Abca5 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 6

 ATP-binding cassette sub-family A member 6 ELISA Kit
 ATP-binding cassette sub-family A member 6 Recombinant
 ATP-binding cassette sub-family A member 6 Antibody
ABCA6: Probable transporter which may play a role in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Com
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ponent: intracellular membrane-bound organelle

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: lipid transport
 ABCA6 ELISA Kit
 ABCA6 Recombinant
 ABCA6 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 7

 ATP-binding cassette sub-family A member 7 ELISA Kit
 ATP-binding cassette sub-family A member 7 Recombinant
 ATP-binding cassette sub-family A member 7 Antibody
ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splici
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ng.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: apical plasma membrane; cell junction; cell surface; Golgi apparatus; intracellular; intracellular membrane-bound organelle; membrane; phagocytic cup; plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; phospholipid transporter activity; protein binding

Biological Process: cholesterol efflux; memory; negative regulation of amyloid precursor protein biosynthetic process; peptide cross-linking; phospholipid efflux; phospholipid translocation; positive regulation of phagocytosis
 Abca7 ELISA Kit
 Abca7 Recombinant
 Abca7 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 8

 ATP-binding cassette sub-family A member 8 ELISA Kit
 ATP-binding cassette sub-family A member 8 Recombinant
 ATP-binding cassette sub-family A member 8 Antibody
ABCA8: ATP-dependent lipophilic drug transporter. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: m
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itochondrial inner membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity

Biological Process: lipid transport; transmembrane transport; transport
 ABCA8 ELISA Kit
 ABCA8 Recombinant
 ABCA8 Antibody
 KIAA0822 ELISA Kit
 KIAA0822 Recombinant
 KIAA0822 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 8-A

 ATP-binding cassette sub-family A member 8-A ELISA Kit
 ATP-binding cassette sub-family A member 8-A Recombinant
 ATP-binding cassette sub-family A member 8-A Antibody
ABCA8A: ATP-dependent lipophilic drug transporter. Belongs to the ABC transporter superfamily. ABCA family.

Protein type: Membrane protein, integral; Transporter

Cellular Component: mitochondrial inner membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: lipid transport; transmembrane transport
 Abca8a ELISA Kit
 Abca8a Recombinant
 Abca8a Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 8-B

 ATP-binding cassette sub-family A member 8-B ELISA Kit
 ATP-binding cassette sub-family A member 8-B Recombinant
 ATP-binding cassette sub-family A member 8-B Antibody
ABCA8: ATP-dependent lipophilic drug transporter. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Cellular Component: mitochondrial inner membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: lipid transport; transport
 Abca8b ELISA Kit
 Abca8b Recombinant
 Abca8b Antibody
 Abca8 ELISA Kit
 Abca8 Recombinant
 Abca8 Antibody
 Kiaa0822 ELISA Kit
 Kiaa0822 Recombinant
 Kiaa0822 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family A member 9

 ATP-binding cassette sub-family A member 9 ELISA Kit
 ATP-binding cassette sub-family A member 9 Recombinant
 ATP-binding cassette sub-family A member 9 Antibody
ABCA9: May play a role in monocyte differentiation and lipid homeostasis. Belongs to the ABC transporter superfamily. ABCA family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: mitochondrial inner membrane; mitochondrion

Molec
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ular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: lipid transport; transmembrane transport
 Abca9 ELISA Kit
 Abca9 Recombinant
 Abca9 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family B member 10

 ATP-binding cassette sub-family B member 10 ELISA Kit
 ATP-binding cassette sub-family B member 10 Recombinant
 ATP-binding cassette sub-family B member 10 Antibody
Also known as ATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein).
ABCB10: May mediate critical mitochondrial transport functions related to heme biosynthesis. Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfa
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mily.

Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; protein binding; protein homodimerization activity; transporter activity

Biological Process: transmembrane transport
 Abcb10 ELISA Kit
 Abcb10 Recombinant
 Abcb10 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family B member 5

 ATP-binding cassette sub-family B member 5 ELISA Kit
 ATP-binding cassette sub-family B member 5 Recombinant
 ATP-binding cassette sub-family B member 5 Antibody
Also known as ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5).
ABCB5: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC
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3.A.1.201) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; efflux transmembrane transporter activity; xenobiotic-transporting ATPase activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; compound eye corneal lens development; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; regulation of membrane potential; transmembrane transport
 ABCB5 ELISA Kit
 ABCB5 Recombinant
 ABCB5 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family B member 6

 ATP-binding cassette sub-family B member 6 ELISA Kit
 ATP-binding cassette sub-family B member 6 Recombinant
 ATP-binding cassette sub-family B member 6 Antibody
Also known as ATP-binding cassette sub-family B member 6, mitochondrial.
Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis ().
 abcb6 ELISA Kit
 abcb6 Recombinant
 abcb6 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family B member 7

 ATP-binding cassette sub-family B member 7 ELISA Kit
 ATP-binding cassette sub-family B member 7 Recombinant
 ATP-binding cassette sub-family B member 7 Antibody
Also known as ATP-binding cassette sub-family B member 7, mitochondrial (ATP-binding cassette transporter 7) (ABC transporter 7 protein).
ABCB7: Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. Defects in ABCB7 are the cause of X-linked sideroblastic anemia with at
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axia (ASAT). ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis. Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function: ATPase activity, coupled to transmembrane movement of substances

Biological Process: cellular iron ion homeostasis; transmembrane transport
 Abcb7 ELISA Kit
 Abcb7 Recombinant
 Abcb7 Antibody
 Abc7 ELISA Kit
 Abc7 Recombinant
 Abc7 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family B member 8

 ATP-binding cassette sub-family B member 8 ELISA Kit
 ATP-binding cassette sub-family B member 8 Recombinant
 ATP-binding cassette sub-family B member 8 Antibody
Also known as ATP-binding cassette sub-family B member 8, mitochondrial.
 abcb8 ELISA Kit
 abcb8 Recombinant
 abcb8 Antibody
 zgc:113037 ELISA Kit
 zgc:113037 Recombinant
 zgc:113037 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family B member 9

 ATP-binding cassette sub-family B member 9 ELISA Kit
 ATP-binding cassette sub-family B member 9 Recombinant
 ATP-binding cassette sub-family B member 9 Antibody
Also known as ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL).
ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an op
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timum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: early endosome; endoplasmic reticulum; integral to endoplasmic reticulum membrane; integral to membrane; lysosomal membrane; lysosome

Molecular Function: ATP binding; oligopeptide-transporting ATPase activity; peptide-transporting ATPase activity; protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; transmembrane transport
 ABCB9 ELISA Kit
 ABCB9 Recombinant
 ABCB9 Antibody
 KIAA1520 ELISA Kit
 KIAA1520 Recombinant
 KIAA1520 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family C member 11

 ATP-binding cassette sub-family C member 11 ELISA Kit
 ATP-binding cassette sub-family C member 11 Recombinant
 ATP-binding cassette sub-family C member 11 Antibody
Also known as ATP-binding cassette sub-family C member 11 (Multidrug resistance-associated protein 8).
ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conju
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gates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity

Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport

Disease: Apocrine Gland Secretion, Variation In
 ABCC11 ELISA Kit
 ABCC11 Recombinant
 ABCC11 Antibody
 MRP8 ELISA Kit
 MRP8 Recombinant
 MRP8 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family C member 8

 ATP-binding cassette sub-family C member 8 ELISA Kit
 ATP-binding cassette sub-family C member 8 Recombinant
 ATP-binding cassette sub-family C member 8 Antibody
Also known as ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1).
ABCC8: a multi-pass membrane protein subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Associates with Kir6.2. Defects in ABCC8 are a cause of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) [MIM:601820, 256450], and may cont
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ribute to non-insulin-dependent diabetes mellitus (NIDDM) in Northern European Caucasians. Two alternatively spliced human isoforms have been described.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
 ABCC8 ELISA Kit
 ABCC8 Recombinant
 ABCC8 Antibody
 SUR ELISA Kit
 SUR Recombinant
 SUR Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family C member 9

 ATP-binding cassette sub-family C member 9 ELISA Kit
 ATP-binding cassette sub-family C member 9 Recombinant
 ATP-binding cassette sub-family C member 9 Antibody
Also known as ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2).
ABCC9: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O); also known as dilated cardio
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myopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12). ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Defects in ABCC9 are the cause of hypertrichotic osteochondrodysplasia (HTOCD). A rare disorder characterized by congenital hypertrichosis, neonatal macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. The hypertrichosis leads to thick scalp hair, which extends onto the forehead, and a general increase in body hair. In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder. About half of affected individuals are macrosomic and edematous at birth, whereas in childhood they usually have a muscular appearance with little subcutaneous fat. Thickened calvarium, narrow thorax, wide ribs, flattened or ovoid vertebral bodies, coxa valga, osteopenia, enlarged medullary canals, and metaphyseal widening of long bones have been reported. Cardiac manifestations such as patent ductus arteriosus, ventricular hypertrophy, pulmonary hypertension, and pericardial effusions are present in approximately 80% of cases. Motor development is usually delayed due to hypotonia. Most patients have a mild speech delay, and a small percentage have learning difficulties or intellectual disability. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: ATP-sensitive potassium channel complex; plasma membrane; voltage-gated potassium channel complex

Molecular Function: anion transmembrane-transporting ATPase activity; potassium channel regulator activity; sulfonylurea receptor activity; transporter activity

Biological Process: defense response to virus; potassium ion import; potassium ion transport; transmembrane transport

Disease: Atrial Fibrillation, Familial, 12; Cantu Syndrome; Cardiomyopathy, Dilated, 1o
 ABCC9 ELISA Kit
 ABCC9 Recombinant
 ABCC9 Antibody
 SUR2 ELISA Kit
 SUR2 Recombinant
 SUR2 Antibody
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ATP-binding cassette sub-family C member Sur

 ATP-binding cassette sub-family C member Sur ELISA Kit
 ATP-binding cassette sub-family C member Sur Recombinant
 ATP-binding cassette sub-family C member Sur Antibody
Also known as ATP-binding cassette sub-family C member Sur (Sulfonylurea receptor) (Dsur).
May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure
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under conditions of tachycardic stress.
 Sur ELISA Kit
 Sur Recombinant
 Sur Antibody
 CG5772 ELISA Kit
 CG5772 Recombinant
 CG5772 Antibody
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ATP-binding cassette sub-family D member 1

 ATP-binding cassette sub-family D member 1 ELISA Kit
 ATP-binding cassette sub-family D member 1 Recombinant
 ATP-binding cassette sub-family D member 1 Antibody
Also known as ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy protein) (ALDP).
ABCD1: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. Defects in ABCD1 are the cause of adrenoleukodystrophy X- linked (X-ALD). X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist
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like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype. The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Cellular Component: cytoplasm; integral to peroxisomal membrane; membrane; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity; enzyme binding; long-chain fatty acid transporter activity; peroxisomal fatty acyl CoA transporter activity; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; long-chain fatty acid catabolic process; peroxisomal long-chain fatty acid import; peroxisome organization and biogenesis; very-long-chain fatty acid catabolic process
 Abcd1 ELISA Kit
 Abcd1 Recombinant
 Abcd1 Antibody
 Ald ELISA Kit
 Ald Recombinant
 Ald Antibody
 Aldgh ELISA Kit
 Aldgh Recombinant
 Aldgh Antibody
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ATP-binding cassette sub-family D member 2

 ATP-binding cassette sub-family D member 2 ELISA Kit
 ATP-binding cassette sub-family D member 2 Recombinant
 ATP-binding cassette sub-family D member 2 Antibody
Also known as ATP-binding cassette sub-family D member 2 (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR).
ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytosol; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome

Molecular Function: long-c
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hain fatty acid transporter activity; protein binding; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process
 ABCD2 ELISA Kit
 ABCD2 Recombinant
 ABCD2 Antibody
 ALD1 ELISA Kit
 ALD1 Recombinant
 ALD1 Antibody
 ALDL1 ELISA Kit
 ALDL1 Recombinant
 ALDL1 Antibody
 ALDR ELISA Kit
 ALDR Recombinant
 ALDR Antibody
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ATP-binding cassette sub-family D member 3

 ATP-binding cassette sub-family D member 3 ELISA Kit
 ATP-binding cassette sub-family D member 3 Recombinant
 ATP-binding cassette sub-family D member 3 Antibody
Also known as ATP-binding cassette sub-family D member 3 (68 kDa peroxisomal membrane protein) (PMP68) (70 kDa peroxisomal membrane protein) (PMP70).
ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs
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in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family

Cellular Component: intracellular membrane-bound organelle; membrane; mitochondrial inner membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity; protein binding; protein homodimerization activity; protein self-association

Biological Process: fatty acid beta-oxidation; fatty acid biosynthetic process; peroxisome organization and biogenesis; very-long-chain fatty acid catabolic process
 Abcd3 ELISA Kit
 Abcd3 Recombinant
 Abcd3 Antibody
 Pmp70 ELISA Kit
 Pmp70 Recombinant
 Pmp70 Antibody
 Pxmp1 ELISA Kit
 Pxmp1 Recombinant
 Pxmp1 Antibody
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ATP-binding cassette sub-family D member 4

 ATP-binding cassette sub-family D member 4 ELISA Kit
 ATP-binding cassette sub-family D member 4 Recombinant
 ATP-binding cassette sub-family D member 4 Antibody
Also known as ATP-binding cassette sub-family D member 4 (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69).
ABCD4: is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamili
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es (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: endoplasmic reticulum membrane; peroxisome

Biological Process: cobalamin metabolic process
 Abcd4 ELISA Kit
 Abcd4 Recombinant
 Abcd4 Antibody
 Pxmp1l ELISA Kit
 Pxmp1l Recombinant
 Pxmp1l Antibody
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ATP-binding cassette sub-family E member 1

 ATP-binding cassette sub-family E member 1 ELISA Kit
 ATP-binding cassette sub-family E member 1 Recombinant
 ATP-binding cassette sub-family E member 1 Antibody
Also known as ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I).
ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the A
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BC transporter superfamily. ABCE family.

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cytoplasm; eukaryotic translation initiation factor 3 complex; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; iron ion binding; protein binding; ribosomal small subunit binding

Biological Process: ribosome export from nucleus; translational initiation; translational termination; transmembrane transport
 ABCE1 ELISA Kit
 ABCE1 Recombinant
 ABCE1 Antibody
 RLI ELISA Kit
 RLI Recombinant
 RLI Antibody
 RNASEL1 ELISA Kit
 RNASEL1 Recombinant
 RNASEL1 Antibody
 RNASELI ELISA Kit
 RNASELI Recombinant
 RNASELI Antibody
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ATP-binding cassette sub-family F member 1

 ATP-binding cassette sub-family F member 1 ELISA Kit
 ATP-binding cassette sub-family F member 1 Recombinant
 ATP-binding cassette sub-family F member 1 Antibody
Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis ().
 ABCF1 ELISA Kit
 ABCF1 Recombinant
 ABCF1 Antibody
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ATP-binding cassette sub-family F member 2

 ATP-binding cassette sub-family F member 2 ELISA Kit
 ATP-binding cassette sub-family F member 2 Recombinant
 ATP-binding cassette sub-family F member 2 Antibody
 ABCF2 ELISA Kit
 ABCF2 Recombinant
 ABCF2 Antibody
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ATP-binding cassette sub-family F member 3

 ATP-binding cassette sub-family F member 3 ELISA Kit
 ATP-binding cassette sub-family F member 3 Recombinant
 ATP-binding cassette sub-family F member 3 Antibody
ABCF3: Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: cell-cell adherens junction; membrane

Molecular Function:
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protein binding
 ABCF3 ELISA Kit
 ABCF3 Recombinant
 ABCF3 Antibody
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ATP-binding cassette sub-family G member 1

 ATP-binding cassette sub-family G member 1 ELISA Kit
 ATP-binding cassette sub-family G member 1 Recombinant
 ATP-binding cassette sub-family G member 1 Antibody
Also known as ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog).
ABCG1: Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane
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protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: endosome; external side of plasma membrane; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; plasma membrane; recycling endosome

Molecular Function: ADP binding; ATP binding; cholesterol transporter activity; phospholipid transporter activity; protein heterodimerization activity; protein homodimerization activity; sterol-transporting ATPase activity; toxin transporter activity

Biological Process: amyloid precursor protein catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; intracellular cholesterol transport; phospholipid efflux; phospholipid homeostasis; positive regulation of cholesterol biosynthetic process; regulation of transcription, DNA-dependent; response to high density lipoprotein stimulus; response to lipid; response to organic substance; reverse cholesterol transport
 Abcg1 ELISA Kit
 Abcg1 Recombinant
 Abcg1 Antibody
 Abc8 ELISA Kit
 Abc8 Recombinant
 Abc8 Antibody
 Wht1 ELISA Kit
 Wht1 Recombinant
 Wht1 Antibody
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ATP-binding cassette sub-family G member 2

 ATP-binding cassette sub-family G member 2 ELISA Kit
 ATP-binding cassette sub-family G member 2 Recombinant
 ATP-binding cassette sub-family G member 2 Antibody
Also known as ATP-binding cassette sub-family G member 2 (Brain multidrug resistance protein) (Urate exporter) (CD antigen CD338).
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, an
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d cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain ().
 ABCG2 ELISA Kit
 ABCG2 Recombinant
 ABCG2 Antibody
 BMDP ELISA Kit
 BMDP Recombinant
 BMDP Antibody
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ATP-binding cassette sub-family G member 3

 ATP-binding cassette sub-family G member 3 ELISA Kit
 ATP-binding cassette sub-family G member 3 Recombinant
 ATP-binding cassette sub-family G member 3 Antibody
ABCG3: is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; thi
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s suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, integral; Transporter

Cellular Component: integral to membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; drug transporter activity

Biological Process: multidrug transport; transmembrane transport
 Abcg3 ELISA Kit
 Abcg3 Recombinant
 Abcg3 Antibody
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ATP-binding cassette sub-family G member 4

 ATP-binding cassette sub-family G member 4 ELISA Kit
 ATP-binding cassette sub-family G member 4 Recombinant
 ATP-binding cassette sub-family G member 4 Antibody
ABCG4: May be involved in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to membrane; plasma mem
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brane

Molecular Function: cholesterol transporter activity; protein binding; protein heterodimerization activity; protein homodimerization activity; sterol-transporting ATPase activity

Biological Process: cholesterol efflux; transmembrane transport
 ABCG4 ELISA Kit
 ABCG4 Recombinant
 ABCG4 Antibody
 WHITE2 ELISA Kit
 WHITE2 Recombinant
 WHITE2 Antibody
Table BarTOPTable Bar
 

ATP-binding cassette sub-family G member 5

 ATP-binding cassette sub-family G member 5 ELISA Kit
 ATP-binding cassette sub-family G member 5 Recombinant
 ATP-binding cassette sub-family G member 5 Antibody
Also known as ATP-binding cassette sub-family G member 5 (Sterolin-1).
ATP-transporter family member that may regulate absorption of dietary cholesterol; human homolog is mutated in sitosterolemia, a disease of hyperabsorption of cholesterol and other sterols [RGD, Feb 2006]
 Abcg5 ELISA Kit
 Abcg5 Recombinant
 Abcg5 Antibody
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ATP-binding cassette sub-family G member 8

 ATP-binding cassette sub-family G member 8 ELISA Kit
 ATP-binding cassette sub-family G member 8 Recombinant
 ATP-binding cassette sub-family G member 8 Antibody
Also known as ATP-binding cassette sub-family G member 8 (Sterolin-2).
ABCG8: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4). With an overal
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l prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries. Defects in ABCG8 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: apical plasma membrane; ATP-binding cassette (ABC) transporter complex; plasma membrane; receptor complex

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; protein binding; protein heterodimerization activity

Biological Process: cholesterol absorption; cholesterol efflux; cholesterol homeostasis; excretion; negative regulation of cholesterol absorption; sterol transport; transmembrane transport

Disease: Gallbladder Disease 4; Sitosterolemia
 ABCG8 ELISA Kit
 ABCG8 Recombinant
 ABCG8 Antibody
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Proteins Root Name Listing
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