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Atrial natriuretic peptide-converting enzyme

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Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.; Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Below are the list of possible Atrial natriuretic peptide-converting enzyme products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Atrial natriuretic peptide-converting enzyme

 Atrial natriuretic peptide-converting enzyme ELISA Kit
 Atrial natriuretic peptide-converting enzyme Recombinant
 Atrial natriuretic peptide-converting enzyme Antibody
Also known as Atrial natriuretic peptide-converting enzyme (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10).
CORIN: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodelin
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g in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: plasma membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: female pregnancy; peptide hormone processing; regulation of blood pressure; regulation of systemic arterial blood pressure by atrial natriuretic peptide

Disease: Preeclampsia/eclampsia 5
 CORIN ELISA Kit
 CORIN Recombinant
 CORIN Antibody
 CRN ELISA Kit
 CRN Recombinant
 CRN Antibody
 TMPRSS10 ELISA Kit
 TMPRSS10 Recombinant
 TMPRSS10 Antibody
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