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Atypical chemokine receptor

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Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).

Below are the list of possible Atypical chemokine receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Atypical chemokine receptor 1

 Atypical chemokine receptor 1 ELISA Kit
 Atypical chemokine receptor 1 Recombinant
 Atypical chemokine receptor 1 Antibody
Also known as Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (CD antigen CD234).
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamili
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es but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels ().
 ACKR1 ELISA Kit
 ACKR1 Recombinant
 ACKR1 Antibody
 DARC ELISA Kit
 DARC Recombinant
 DARC Antibody
 FY ELISA Kit
 FY Recombinant
 FY Antibody
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Atypical chemokine receptor 2

 Atypical chemokine receptor 2 ELISA Kit
 Atypical chemokine receptor 2 Recombinant
 Atypical chemokine receptor 2 Antibody
Also known as Atypical chemokine receptor 2 (C-C chemokine receptor D6) (CCR10-related receptor) (Chemokine-binding protein 2) (Chemokine-binding protein D6).
CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: actin filament; plasma membrane

Molecular Function: C-C chemokine binding; C-C chemokine receptor activity; scavenger receptor acti
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vity

Biological Process: signal transduction
 Ackr2 ELISA Kit
 Ackr2 Recombinant
 Ackr2 Antibody
 Ccbp2 ELISA Kit
 Ccbp2 Recombinant
 Ccbp2 Antibody
 Ccr10rr ELISA Kit
 Ccr10rr Recombinant
 Ccr10rr Antibody
 D6 ELISA Kit
 D6 Recombinant
 D6 Antibody
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Atypical chemokine receptor 3

 Atypical chemokine receptor 3 ELISA Kit
 Atypical chemokine receptor 3 Recombinant
 Atypical chemokine receptor 3 Antibody
Also known as Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1).
CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Requ
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ired for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cell surface; coated pit; endosome; intracellular membrane-bound organelle; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; protein binding; scavenger receptor activity

Biological Process: receptor internalization
 ACKR3 ELISA Kit
 ACKR3 Recombinant
 ACKR3 Antibody
 CMKOR1 ELISA Kit
 CMKOR1 Recombinant
 CMKOR1 Antibody
 CXCR7 ELISA Kit
 CXCR7 Recombinant
 CXCR7 Antibody
 GPR159 ELISA Kit
 GPR159 Recombinant
 GPR159 Antibody
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Atypical chemokine receptor 4

 Atypical chemokine receptor 4 ELISA Kit
 Atypical chemokine receptor 4 Recombinant
 Atypical chemokine receptor 4 Antibody
Also known as Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR).
CCRL1: Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Molecular Function: chemokine receptor activity
 Ackr4 ELISA Kit
 Ackr4 Recombinant
 Ackr4 Antibody
 Ccr11 ELISA Kit
 Ccr11 Recombinant
 Ccr11 Antibody
 Ccrl1 ELISA Kit
 Ccrl1 Recombinant
 Ccrl1 Antibody
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