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Axin

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Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).

Below are the list of possible Axin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Axin

 Axin ELISA Kit
 Axin Recombinant
 Axin Antibody
Also known as Axin (Axis inhibition protein) (d-Axin) (dAxin).
Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).
 Axn ELISA Kit
 Axn Recombinant
 Axn Antibody
 CG7926 ELISA Kit
 CG7926 Recombinant
 CG7926 Antibody
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Axin-1

 Axin-1 ELISA Kit
 Axin-1 Recombinant
 Axin-1 Antibody
Also known as Axin-1 (Axis inhibition protein 1).
Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
 axin1 ELISA Kit
 axin1 Recombinant
 axin1 Antibody
 axin ELISA Kit
 axin Recombinant
 axin Antibody
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Axin-2

 Axin-2 ELISA Kit
 Axin-2 Recombinant
 Axin-2 Antibody
Also known as Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin).
axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitinat
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ion and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q24.1

Cellular Component: beta-catenin destruction complex; cell cortex; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; Golgi apparatus; microtubule cytoskeleton; nucleoplasm; nucleus; plasma membrane; postsynaptic density

Molecular Function: beta-catenin binding; enzyme binding; GTPase activator activity; protein binding; protein kinase binding; ubiquitin protein ligase binding

Biological Process: dorsal/ventral axis specification; intramembranous ossification; maintenance of DNA repeat elements; mRNA stabilization; negative regulation of cell proliferation; negative regulation of osteoblast differentiation; odontogenesis; positive regulation of protein amino acid phosphorylation; regulation of mismatch repair; regulation of transcription, DNA-dependent; Wnt receptor signaling pathway

Disease: Oligodontia-colorectal Cancer Syndrome
 AXIN2 ELISA Kit
 AXIN2 Recombinant
 AXIN2 Antibody
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