| B-cell antigen receptor complex-associated protein beta chain ELISA Kit|
B-cell antigen receptor complex-associated protein beta chain Recombinant
B-cell antigen receptor complex-associated protein beta chain Antibody
|Also known as B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b). |
Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late
endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: B cell receptor complex; cytoplasm; external side of plasma membrane; Golgi apparatus; integral to plasma membrane; nucleoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: B cell differentiation; B cell receptor signaling pathway
| Cd79b ELISA Kit|
| Igb ELISA Kit|