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B-cell lymphoma 6 protein

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Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Below are the list of possible B-cell lymphoma 6 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

B-cell lymphoma 6 protein

 B-cell lymphoma 6 protein ELISA Kit
 B-cell lymphoma 6 protein Recombinant
 B-cell lymphoma 6 protein Antibody
Also known as B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51).
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequentl
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y translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
 BCL6 ELISA Kit
 BCL6 Recombinant
 BCL6 Antibody
 BCL5 ELISA Kit
 BCL5 Recombinant
 BCL5 Antibody
 LAZ3 ELISA Kit
 LAZ3 Recombinant
 LAZ3 Antibody
 ZBTB27 ELISA Kit
 ZBTB27 Recombinant
 ZBTB27 Antibody
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B-cell lymphoma 6 protein homolog

 B-cell lymphoma 6 protein homolog ELISA Kit
 B-cell lymphoma 6 protein homolog Recombinant
 B-cell lymphoma 6 protein homolog Antibody
Bcl-6: a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocate
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d and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL.

Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor

Cellular Component: nucleus; replication fork

Molecular Function: chromatin binding; chromatin DNA binding; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: actin cytoskeleton organization and biogenesis; B cell differentiation; cell morphogenesis; erythrocyte development; germinal center formation; negative regulation of apoptosis; negative regulation of cell differentiation; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of isotype switching to IgE isotypes; negative regulation of mast cell cytokine production; negative regulation of Notch signaling pathway; negative regulation of Rho protein signal transduction; negative regulation of T-helper 2 cell differentiation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of B cell proliferation; positive regulation of cell motility; positive regulation of histone deacetylation; positive regulation of neuron differentiation; protein import into nucleus, translocation; protein localization; regulation of cell proliferation; regulation of GTPase activity; regulation of inflammatory response; regulation of memory T cell differentiation; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; Rho protein signal transduction; spermatogenesis; T-helper 2 type immune response
 Bcl6 ELISA Kit
 Bcl6 Recombinant
 Bcl6 Antibody
 Bcl-6 ELISA Kit
 Bcl-6 Recombinant
 Bcl-6 Antibody
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