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B-cell lymphoma/leukemia

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Involved in adaptive immune response .

Below are the list of possible B-cell lymphoma/leukemia products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

B-cell lymphoma/leukemia 10

 B-cell lymphoma/leukemia 10 ELISA Kit
 B-cell lymphoma/leukemia 10 Recombinant
 B-cell lymphoma/leukemia 10 Antibody
Also known as B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10).
Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates v
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ia CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: cytoplasm; cytoplasmic microtubule; cytosol; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex

Molecular Function: enzyme binding; identical protein binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell death; innate immune response; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein oligomerization; response to food; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway

Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor
 BCL10 ELISA Kit
 BCL10 Recombinant
 BCL10 Antibody
 CIPER ELISA Kit
 CIPER Recombinant
 CIPER Antibody
 CLAP ELISA Kit
 CLAP Recombinant
 CLAP Antibody
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B-cell lymphoma/leukemia 11A

 B-cell lymphoma/leukemia 11A ELISA Kit
 B-cell lymphoma/leukemia 11A Recombinant
 B-cell lymphoma/leukemia 11A Antibody
Also known as B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856).
Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q3
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2.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: nucleoplasm

Biological Process: negative regulation of transcription from RNA polymerase II promoter; protein sumoylation; signal transduction

Disease: Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin
 BCL11A ELISA Kit
 BCL11A Recombinant
 BCL11A Antibody
 CTIP1 ELISA Kit
 CTIP1 Recombinant
 CTIP1 Antibody
 EVI9 ELISA Kit
 EVI9 Recombinant
 EVI9 Antibody
 KIAA1809 ELISA Kit
 KIAA1809 Recombinant
 KIAA1809 Antibody
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B-cell lymphoma/leukemia 11B

 B-cell lymphoma/leukemia 11B ELISA Kit
 B-cell lymphoma/leukemia 11B Recombinant
 B-cell lymphoma/leukemia 11B Antibody
Also known as B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1).
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encodi
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ng distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
 BCL11B ELISA Kit
 BCL11B Recombinant
 BCL11B Antibody
 CTIP2 ELISA Kit
 CTIP2 Recombinant
 CTIP2 Antibody
 RIT1 ELISA Kit
 RIT1 Recombinant
 RIT1 Antibody
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