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Beclin 1-associated autophagy-related key regulator

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Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism (By similarity).

Below are the list of possible Beclin 1-associated autophagy-related key regulator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Beclin 1-associated autophagy-related key regulator

 Beclin 1-associated autophagy-related key regulator ELISA Kit
 Beclin 1-associated autophagy-related key regulator Recombinant
 Beclin 1-associated autophagy-related key regulator Antibody
Also known as Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L).
Barkor: Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-d
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ependent manner. Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with PIK3CB. Belongs to the Barkor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Cellular Component: autophagic vacuole; axoneme; cytoplasm; nucleus; phagocytic vesicle; pre-autophagosomal structure membrane

Biological Process: autophagic vacuole formation; autophagy; cellular response to glucose starvation; cellular response to starvation; endosome to lysosome transport; macroautophagy; negative regulation of protein amino acid phosphorylation; positive regulation of autophagy; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; regulation of protein amino acid phosphorylation
 Atg14 ELISA Kit
 Atg14 Recombinant
 Atg14 Antibody
 Atg14L ELISA Kit
 Atg14L Recombinant
 Atg14L Antibody
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