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Beta-adrenergic receptor kinase

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Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Below are the list of possible Beta-adrenergic receptor kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Beta-adrenergic receptor kinase 1

 Beta-adrenergic receptor kinase 1 ELISA Kit
 Beta-adrenergic receptor kinase 1 Recombinant
 Beta-adrenergic receptor kinase 1 Antibody
Also known as Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled receptor kinase 2).
GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve ca
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rdiac function.

Protein type: AGC group; BARK subfamily; EC 2.7.11.15; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: cytoplasm; cytosol; membrane; plasma membrane

Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled receptor kinase activity; protein binding; protein kinase activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; cardiac muscle contraction; desensitization of G-protein coupled receptor protein signaling pathway; entry of virus into host cell; negative regulation of striated muscle contraction; negative regulation of the force of heart contraction by chemical signal; peptidyl-serine phosphorylation; positive regulation of catecholamine secretion; receptor internalization; tachykinin signaling pathway; viral genome replication
 GRK2 ELISA Kit
 GRK2 Recombinant
 GRK2 Antibody
 ADRBK1 ELISA Kit
 ADRBK1 Recombinant
 ADRBK1 Antibody
 BARK ELISA Kit
 BARK Recombinant
 BARK Antibody
 BARK1 ELISA Kit
 BARK1 Recombinant
 BARK1 Antibody
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Beta-adrenergic receptor kinase 2

 Beta-adrenergic receptor kinase 2 ELISA Kit
 Beta-adrenergic receptor kinase 2 Recombinant
 Beta-adrenergic receptor kinase 2 Antibody
Also known as Beta-adrenergic receptor kinase 2 (Beta-ARK-2).
GRK3: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Protein type: AGC group; BARK subfamily; EC 2.7.11.15; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase,
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Ser/Thr (non-receptor)

Cellular Component: axon; cilium; cytosol; dendritic shaft; dendritic spine; membrane; nucleus; perinuclear region of cytoplasm; synapse; Z disc

Molecular Function: beta-adrenergic receptor kinase activity; D1 dopamine receptor binding; G-protein coupled receptor kinase activity

Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; inositol phosphate metabolic process; intracellular protein transport; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; receptor internalization; rhodopsin metabolic process
 Adrbk2 ELISA Kit
 Adrbk2 Recombinant
 Adrbk2 Antibody
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