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Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

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Below are the list of possible Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase ELISA Kit
 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Recombinant
 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Antibody
Also known as Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase).
GNE: Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transdu
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ction, tumorigenicity and metastatic behavior of malignant cells. Defects in GNE are a cause of sialuria (SIALURIA); also known as sialuria French type. In sialuria, free sialic acid accumulates in the cytoplasm and gram quantities of neuraminic acid are secreted in the urine. The metabolic defect involves lack of feedback inhibition of UDP-GlcNAc 2-epimerase by CMP-Neu5Ac, resulting in constitutive overproduction of free Neu5Ac. Clinical features include variable degrees of developmental delay, coarse facial features and hepatomegaly. Sialuria inheritance is autosomal dominant. Defects in GNE are the cause of inclusion body myopathy type 2 (IBM2). Hereditary inclusion body myopathies are a group of neuromuscular disorders characterized by adult onset, slowly progressive distal and proximal weakness and a typical muscle pathology including rimmed vacuoles and filamentous inclusions. IBM2 is an autosomal recessive disorder affecting mainly leg muscles, but with an unusual distribution that spares the quadriceps as also observed in Nonaka myopathy. Defects in GNE are the cause of Nonaka myopathy (NM); also known as distal myopathy with rimmed vacuoles (DMRV). NM is an autosomal recessive muscular disorder, allelic to inclusion body myopathy 2. It is characterized by weakness of the anterior compartment of the lower limbs with onset in early adulthood, and sparing of the quadriceps muscles. As the inclusion body myopathy, NM is histologically characterized by the presence of numerous rimmed vacuoles without inflammatory changes in muscle specimens. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Cell adhesion; Cytoskeletal; EC 2.7.1.60; EC 3.2.1.183; Isomerase; Kinase, other; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cytoplasm; cytosol

Molecular Function: N-acylmannosamine kinase activity; protein binding; UDP-N-acetylglucosamine 2-epimerase activity

Biological Process: cell adhesion; N-acetylneuraminate metabolic process

Disease: Inclusion Body Myopathy 2, Autosomal Recessive; Nonaka Myopathy; Sialuria
 GNE ELISA Kit
 GNE Recombinant
 GNE Antibody
 GLCNE ELISA Kit
 GLCNE Recombinant
 GLCNE Antibody
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