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Bile salt export pump

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Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Below are the list of possible Bile salt export pump products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Bile salt export pump

 Bile salt export pump ELISA Kit
 Bile salt export pump Recombinant
 Bile salt export pump Antibody
Also known as Bile salt export pump (ATP-binding cassette sub-family B member 11).
ABCB11: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyl
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transferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease. Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2). BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 2q24

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: bile acid-exporting ATPase activity; canalicular bile acid transmembrane transporter activity; sodium-exporting ATPase activity, phosphorylative mechanism; transporter activity

Biological Process: bile acid and bile salt transport; bile acid biosynthetic process; canalicular bile acid transport; transport

Disease: Cholestasis, Benign Recurrent Intrahepatic, 2; Cholestasis, Progressive Familial Intrahepatic, 2
 ABCB11 ELISA Kit
 ABCB11 Recombinant
 ABCB11 Antibody
 BSEP ELISA Kit
 BSEP Recombinant
 BSEP Antibody
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