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Bloom syndrome protein

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Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).

Below are the list of possible Bloom syndrome protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Bloom syndrome protein

 Bloom syndrome protein ELISA Kit
 Bloom syndrome protein Recombinant
 Bloom syndrome protein Antibody
Also known as Bloom syndrome protein (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3).
BLM: a magnesium-dependent ATP-dependent DNA-helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. A member of the RecQ helicase family that is required for genome stability. Participates in DNA replication, recombination and repair. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex which is a dynamic process changing throughout the cell cycle and within subnu
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clear domains. Interacts with ubiquitinated FANCD2.

Protein type: DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: chromosome, telomeric region; cytoplasm; lateral element; nuclear chromosome; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body

Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent helicase activity; ATPase activity; bubble DNA binding; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; p53 binding; protein binding; single-stranded DNA binding

Biological Process: DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of cell division; negative regulation of DNA recombination; positive regulation of transcription, DNA-dependent; protein oligomerization; protein sumoylation; regulation of cyclin-dependent protein kinase activity; replication fork processing; response to DNA damage stimulus; response to X-ray; strand displacement

Disease: Bloom Syndrome
 BLM ELISA Kit
 BLM Recombinant
 BLM Antibody
 RECQ2 ELISA Kit
 RECQ2 Recombinant
 RECQ2 Antibody
 RECQL3 ELISA Kit
 RECQL3 Recombinant
 RECQL3 Antibody
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Bloom syndrome protein homolog

 Bloom syndrome protein homolog ELISA Kit
 Bloom syndrome protein homolog Recombinant
 Bloom syndrome protein homolog Antibody
Also known as Bloom syndrome protein homolog (Dmblm) (Bloom syndrome helicase ortholog) (Mutagen-sensitive protein 309) (RecQ helicase homolog).
Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction ().
 Blm ELISA Kit
 Blm Recombinant
 Blm Antibody
 mus309 ELISA Kit
 mus309 Recombinant
 mus309 Antibody
 CG6920 ELISA Kit
 CG6920 Recombinant
 CG6920 Antibody
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