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Bone morphogenetic protein receptor

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Below are the list of possible Bone morphogenetic protein receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Bone morphogenetic protein receptor type-1A

 Bone morphogenetic protein receptor type-1A ELISA Kit
 Bone morphogenetic protein receptor type-1A Recombinant
 Bone morphogenetic protein receptor type-1A Antibody
Also known as Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292).
BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: EC 2.7.11.30; Kinase, prote
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in; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Cellular Component: caveola; cell soma; dendrite; external side of plasma membrane; plasma membrane

Molecular Function: ATP binding; glycoprotein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; SMAD binding

Biological Process: anterior/posterior pattern formation; BMP signaling pathway; cartilage development; cell differentiation; chondrocyte differentiation; developmental growth; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic digit morphogenesis; embryonic morphogenesis; embryonic organ development; endoderm development; heart development; heart morphogenesis; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; Mullerian duct regression; negative regulation of neurogenesis; negative regulation of smooth muscle cell migration; nervous system development; neural crest cell development; neural plate mediolateral pattern formation; odontogenesis of dentine-containing teeth; palate development; paraxial mesoderm development; paraxial mesoderm structural organization; pattern specification process; pituitary gland development; positive regulation of bone mineralization; positive regulation of cardiac muscle cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; regulation of endothelial cell differentiation; regulation of endothelial cell proliferation; regulation of lateral mesodermal cell fate specification; somitogenesis; stem cell maintenance
 Bmpr1a ELISA Kit
 Bmpr1a Recombinant
 Bmpr1a Antibody
 Acvrlk3 ELISA Kit
 Acvrlk3 Recombinant
 Acvrlk3 Antibody
 Bmpr ELISA Kit
 Bmpr Recombinant
 Bmpr Antibody
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Bone morphogenetic protein receptor type-1B

 Bone morphogenetic protein receptor type-1B ELISA Kit
 Bone morphogenetic protein receptor type-1B Recombinant
 Bone morphogenetic protein receptor type-1B Antibody
Also known as Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (Activin receptor-like kinase 6) (ALK-6) (RPK-1) (Serine/threonine-protein kinase receptor R6) (SKR6).
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosph
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orylate, then bind and activate SMAD transcriptiona (). Positively regulates chondrocyte differentiation (PubMed:24129431).
 BMPR1B ELISA Kit
 BMPR1B Recombinant
 BMPR1B Antibody
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Bone morphogenetic protein receptor type-2

 Bone morphogenetic protein receptor type-2 ELISA Kit
 Bone morphogenetic protein receptor type-2 Recombinant
 Bone morphogenetic protein receptor type-2 Antibody
Also known as Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).
BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand bin
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ding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.

Protein type: Cell cycle regulation; EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: caveola; extracellular space; integral to plasma membrane; intercellular junction; plasma membrane

Molecular Function: activin receptor activity, type II; protein binding

Biological Process: alveolus development; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; cardiac muscle development; cellular response to starvation; chondrocyte development; endothelial cell proliferation; lymphangiogenesis; mesoderm formation; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; negative regulation of vasoconstriction; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of endothelial cell proliferation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; proteoglycan biosynthetic process; regulation of cell proliferation; regulation of lung blood pressure; transcription from RNA polymerase II promoter; transmembrane receptor protein serine/threonine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway

Disease: Pulmonary Hypertension, Primary, 1; Pulmonary Venoocclusive Disease 1, Autosomal Dominant
 BMPR2 ELISA Kit
 BMPR2 Recombinant
 BMPR2 Antibody
 PPH1 ELISA Kit
 PPH1 Recombinant
 PPH1 Antibody
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