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Botulinum neurotoxin

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Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of the three isoforms SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the '197-Gln-|-Arg-198' bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure (By similarity).

Below are the list of possible Botulinum neurotoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Botulinum neurotoxin type A

 Botulinum neurotoxin type A ELISA Kit
 Botulinum neurotoxin type A Recombinant
 Botulinum neurotoxin type A Antibody
Also known as Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX).
Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of the three isoforms SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After tr
>>>
anslocation, the light chain (L) hydrolyzes the '197-Gln-|-Arg-198' bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure ().
 botA ELISA Kit
 botA Recombinant
 botA Antibody
 atx ELISA Kit
 atx Recombinant
 atx Antibody
 bna ELISA Kit
 bna Recombinant
 bna Antibody
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Botulinum neurotoxin type B

 Botulinum neurotoxin type B ELISA Kit
 Botulinum neurotoxin type B Recombinant
 Botulinum neurotoxin type B Antibody
Also known as Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B).
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cl
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eaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2 ().
 botB ELISA Kit
 botB Recombinant
 botB Antibody
 CLD_A0068 ELISA Kit
 CLD_A0068 Recombinant
 CLD_A0068 Antibody
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Botulinum neurotoxin type C1

 Botulinum neurotoxin type C1 ELISA Kit
 Botulinum neurotoxin type C1 Recombinant
 Botulinum neurotoxin type C1 Antibody
Also known as Botulinum neurotoxin type C1 (BoNT/C1) (Bontoxilysin-C1).
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and mo
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ves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves syntaxin.
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Botulinum neurotoxin type C1 non-toxic component

 Botulinum neurotoxin type C1 non-toxic component ELISA Kit
 Botulinum neurotoxin type C1 non-toxic component Recombinant
 Botulinum neurotoxin type C1 non-toxic component Antibody
The non-toxic component is necessary to maintain toxicity.
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Botulinum neurotoxin type D

 Botulinum neurotoxin type D ELISA Kit
 Botulinum neurotoxin type D Recombinant
 Botulinum neurotoxin type D Antibody
Also known as Botulinum neurotoxin type D (BoNT/D) (Bontoxilysin-D).
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cl
>>>
eaves the '60-Lys-|-Leu-61' bond of synaptobrevins-1 and -2.
 botD ELISA Kit
 botD Recombinant
 botD Antibody
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Botulinum neurotoxin type E

 Botulinum neurotoxin type E ELISA Kit
 Botulinum neurotoxin type E Recombinant
 Botulinum neurotoxin type E Antibody
Also known as Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E).
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves
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by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase.
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Botulinum neurotoxin type E non-toxic component

 Botulinum neurotoxin type E non-toxic component ELISA Kit
 Botulinum neurotoxin type E non-toxic component Recombinant
 Botulinum neurotoxin type E non-toxic component Antibody
The non-toxic component is necessary to maintain toxicity.
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Botulinum neurotoxin type F

 Botulinum neurotoxin type F ELISA Kit
 Botulinum neurotoxin type F Recombinant
 Botulinum neurotoxin type F Antibody
Also known as Botulinum neurotoxin type F (BoNT/F) (Bontoxilysin-F).
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that ca
>>>
talyzes the hydrolysis of the '58-Gln-|-Lys-59' bond of synaptobrevins-1 and -2.
 botF ELISA Kit
 botF Recombinant
 botF Antibody
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Botulinum neurotoxin type G

 Botulinum neurotoxin type G ELISA Kit
 Botulinum neurotoxin type G Recombinant
 Botulinum neurotoxin type G Antibody
Also known as Botulinum neurotoxin type G (BoNT/G) (Bontoxilysin-G).
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase.
 botG ELISA Kit
 botG Recombinant
 botG Antibody
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