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Breakpoint cluster region protein

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GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (By similarity).

Below are the list of possible Breakpoint cluster region protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Breakpoint cluster region protein

 Breakpoint cluster region protein ELISA Kit
 Breakpoint cluster region protein Recombinant
 Breakpoint cluster region protein Antibody
Bcr: a protein with serine/threonine protein kinase activity and is a GTPase-activating protein (GAP) for RAC1 and CDC42. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family
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of GTP binding proteins. The carboxy-terminal region promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. A breakpoint cluster region protein that participates in a t(9;22)(q34;q11) chromosomal translocation that produces a BCR-ABL oncogene responsible for chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Tyr177 of human Bcr, phosphorylated in the Bcr-Abl fusion protein, provides a docking site for Gab2 and GRB2, and is important in the transforming activity of Bcr-Abl. Sequence variants of the Bcr protein may be associated with bipolar disorder. Two alternatively spliced isoforms of the human protein have been reported.

Protein type: ATYPICAL group; BCR family; EC 2.7.11.1; GAPs; GAPs, Rac/Rho; GEFs, Rac/Rho; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical

Cellular Component: cytoplasm; cytosol; membrane; plasma membrane; postsynaptic density; protein complex

Molecular Function: enzyme binding; GTPase activator activity; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; brain development; homeostasis of number of cells; inner ear morphogenesis; intracellular protein transport across a membrane; negative regulation of cell migration; negative regulation of cellular extravasation; negative regulation of inflammatory response; negative regulation of neutrophil degranulation; neuromuscular process controlling balance; platelet-derived growth factor receptor signaling pathway; positive regulation of phagocytosis; protein amino acid autophosphorylation; regulation of cell cycle; regulation of nitrogen compound metabolic process; regulation of vascular permeability; renal system process; response to lipopolysaccharide
 Bcr ELISA Kit
 Bcr Recombinant
 Bcr Antibody
 Kiaa3017 ELISA Kit
 Kiaa3017 Recombinant
 Kiaa3017 Antibody
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