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Breast cancer type 1 susceptibility protein

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E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator .

Below are the list of possible Breast cancer type 1 susceptibility protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Breast cancer type 1 susceptibility protein

 Breast cancer type 1 susceptibility protein ELISA Kit
 Breast cancer type 1 susceptibility protein Recombinant
 Breast cancer type 1 susceptibility protein Antibody
Also known as Breast cancer type 1 susceptibility protein (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1).
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit pro
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tein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
 BRCA1 ELISA Kit
 BRCA1 Recombinant
 BRCA1 Antibody
 RNF53 ELISA Kit
 RNF53 Recombinant
 RNF53 Antibody
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Breast cancer type 1 susceptibility protein homolog

 Breast cancer type 1 susceptibility protein homolog ELISA Kit
 Breast cancer type 1 susceptibility protein homolog Recombinant
 Breast cancer type 1 susceptibility protein homolog Antibody
Also known as Breast cancer type 1 susceptibility protein homolog (RING-type E3 ubiquitin transferase BRCA1).
BRCA1: the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function.
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Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACC1 and preventing its dephosphorylation. Defects in BRCA1 are a cause of genetic susceptibility to breast cancer. Mutations in BRCA1 are thought to be responsible for more than 80% of inherited breast-ovarian cancer. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association may be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts (via BRCT domains) with CTIP. Associates with RNA polymerase II holoenzyme. Interacts with SMC1 and COBRA1. Interacts (via BRCT domains) with BRIP1. Interacts with FANCD2 (ubiquitinated). Interacts with BAP1. Interacts with Artemis and claspin. Interacts with H2AFX (phosphorylated on S140). Interacts with CHK1. Interacts with BRCC3. Five human isoforms are produced by alternative splicing and alternative initiation. Isoform 1 and isoform 3 are widely expressed. Isoform 1 is largely nuclear, while isoforms 3 and 5 are cytoplasmic.

Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: BRCA1-BARD1 complex; centrosome; chromosome; condensed chromosome; condensed nuclear chromosome; cytoplasm; lateral element; mitochondrial matrix; nucleus; plasma membrane; protein complex; ribonucleoprotein complex

Molecular Function: chromatin binding; damaged DNA binding; enzyme binding; RNA binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: centrosome cycle; centrosome duplication; chordate embryonic development; chromosome breakage; chromosome segregation; DNA damage response, signal transduction resulting in induction of apoptosis; DNA replication; dosage compensation, by inactivation of X chromosome; double-strand break repair; double-strand break repair via homologous recombination; G2/M transition DNA damage checkpoint; genetic imprinting; negative regulation of estrogen receptor signaling pathway; negative regulation of fatty acid biosynthetic process; negative regulation of histone acetylation; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of transcription, DNA-dependent; positive regulation of angiogenesis; positive regulation of DNA repair; positive regulation of histone acetylation; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 methylation; positive regulation of protein import into nucleus, translocation; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; postreplication repair; protein autoubiquitination; protein ubiquitination; regulation of cell proliferation; response to DNA damage stimulus; response to estrogen stimulus; response to ionizing radiation
 Brca1 ELISA Kit
 Brca1 Recombinant
 Brca1 Antibody
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