Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Breast cancer type 2 susceptibility protein  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • VARICELLA ZOSTER Antibody
 • RNA-binding motif protein, Y chromosome, family 1 member A1 ... Recombinant Protein
 • OAS3 siRNA
 • Beta-Defensins 2 (DEFbeta2) ELISA Kit
 • ADM ELISA Kit
 • Mre11 (Mre11a) Antibody
 • Afadin (MLLT4) ELISA Kit
 • Neuromedin B (NMB) Recombinant Protein
 • S100A8, human Antibody
 • Guanosine 5-Triphosphate Cyclohydrolase1 (GCH1) ELISA Kit
 • TRDMT1 (DNMT2) (TRDMT1 (DNMT2)) Recombinant Protein
 • Aldose reductase (Akr1b1) Recombinant Protein
 • Zilpaterol Antibody
 • D(2) dopamine receptor (Drd2) ELISA Kit
 downarrow more ...
separator

Breast cancer type 2 susceptibility protein

separator
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination .

Below are the list of possible Breast cancer type 2 susceptibility protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Breast cancer type 2 susceptibility protein

 Breast cancer type 2 susceptibility protein ELISA Kit
 Breast cancer type 2 susceptibility protein Recombinant
 Breast cancer type 2 susceptibility protein Antibody
Also known as Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).
BRCA2: involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma.

Protein type: DNA repair, damage; Nuclear receptor co-regulator; Tumor
>>>
suppressor

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: BRCA2-MAGE-D1 complex; centrosome; cytoplasm; lateral element; nuclear chromosome, telomeric region; nucleoplasm; nucleus; protein complex; secretory granule

Molecular Function: gamma-tubulin binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; histone acetyltransferase activity; protease binding; protein binding; protein C-terminus binding; single-stranded DNA binding

Biological Process: centrosome duplication; cytokinesis; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; negative regulation of mammary gland epithelial cell proliferation; nucleotide-excision repair; positive regulation of transcription, DNA-dependent; strand displacement

Disease: Breast Cancer; Breast-ovarian Cancer, Familial, Susceptibility To, 2; Fanconi Anemia, Complementation Group D1; Glioma Susceptibility 3; Medulloblastoma; Pancreatic Cancer, Susceptibility To, 2; Prostate Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Wilms Tumor 1
 BRCA2 ELISA Kit
 BRCA2 Recombinant
 BRCA2 Antibody
 FACD ELISA Kit
 FACD Recombinant
 FACD Antibody
 FANCD1 ELISA Kit
 FANCD1 Recombinant
 FANCD1 Antibody
Table BarTOPTable Bar
 

Breast cancer type 2 susceptibility protein homolog

 Breast cancer type 2 susceptibility protein homolog ELISA Kit
 Breast cancer type 2 susceptibility protein homolog Recombinant
 Breast cancer type 2 susceptibility protein homolog Antibody
Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint ().
 Brca2 ELISA Kit
 Brca2 Recombinant
 Brca2 Antibody
 GD11868 ELISA Kit
 GD11868 Recombinant
 GD11868 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions