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BRISC complex

Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates .

Below are the list of possible BRISC complex products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

BRISC complex subunit Abro1

 BRISC complex subunit Abro1 ELISA Kit
 BRISC complex subunit Abro1 Recombinant
 BRISC complex subunit Abro1 Antibody
Also known as BRISC complex subunit Abro1 (Abraxas brother protein 1) (Protein FAM175B).
FAM175B: a protein of unknown function.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: centrosome; cytoplasm; midbody; spindle pole centrosome

Molecular Function: microtubule binding; polyubiquitin binding

Biological Process: attachment of spindle microtubules to kinetochore; chromosome segregation; mitotic cell cycle
 FAM175B Recombinant
 FAM175B Antibody
 ABRO1 Recombinant
 ABRO1 Antibody
 KIAA0157 Recombinant
 KIAA0157 Antibody
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BRISC complex subunit FAM175B

 BRISC complex subunit FAM175B ELISA Kit
 BRISC complex subunit FAM175B Recombinant
 BRISC complex subunit FAM175B Antibody
Also known as BRISC complex subunit FAM175B (BRISC complex subunit KIAA0157 homolog).
Component of the BRISC complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:26344097). Does not have activity by itself, but the catalytic subunit BRCC3/BRCC36 needs to be associated into a heterotetramer with FAM175B for minimal i
n vitro activity (PubMed:26344097). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1 ().
 EAG_01033 ELISA Kit
 EAG_01033 Recombinant
 EAG_01033 Antibody
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Proteins Root Name Listing
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