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C-Jun-amino-terminal kinase-interacting protein

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The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Below are the list of possible C-Jun-amino-terminal kinase-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

C-Jun-amino-terminal kinase-interacting protein 1

 C-Jun-amino-terminal kinase-interacting protein 1 ELISA Kit
 C-Jun-amino-terminal kinase-interacting protein 1 Recombinant
 C-Jun-amino-terminal kinase-interacting protein 1 Antibody
Also known as C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1).
JIP1: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade. Required for JNK activation in response to excitotoxic stress. Causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and by inhibiting the JNK phosphorylation of c-Jun. May also partici
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pate in ApoER2-specific reelin signaling. Directly or indirectly regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: cytoplasm

Molecular Function: kinesin binding; MAP-kinase scaffold activity; protein binding; protein kinase inhibitor activity

Biological Process: regulation of JNK cascade; vesicle-mediated transport

Disease: Diabetes Mellitus, Noninsulin-dependent
 MAPK8IP1 ELISA Kit
 MAPK8IP1 Recombinant
 MAPK8IP1 Antibody
 IB1 ELISA Kit
 IB1 Recombinant
 IB1 Antibody
 JIP1 ELISA Kit
 JIP1 Recombinant
 JIP1 Antibody
 PRKM8IP ELISA Kit
 PRKM8IP Recombinant
 PRKM8IP Antibody
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C-Jun-amino-terminal kinase-interacting protein 2

 C-Jun-amino-terminal kinase-interacting protein 2 ELISA Kit
 C-Jun-amino-terminal kinase-interacting protein 2 Recombinant
 C-Jun-amino-terminal kinase-interacting protein 2 Antibody
Also known as C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2).
MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components
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and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Activator; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: cytoplasm; postsynaptic density

Molecular Function: kinesin binding; protein binding; protein kinase binding; structural molecule activity

Biological Process: behavioral fear response; dendrite morphogenesis; nonassociative learning; regulation of excitatory postsynaptic membrane potential; regulation of JNK cascade; regulation of receptor activity; regulation of synaptic transmission, glutamatergic; signal complex assembly; social behavior
 MAPK8IP2 ELISA Kit
 MAPK8IP2 Recombinant
 MAPK8IP2 Antibody
 IB2 ELISA Kit
 IB2 Recombinant
 IB2 Antibody
 JIP2 ELISA Kit
 JIP2 Recombinant
 JIP2 Antibody
 PRKM8IPL ELISA Kit
 PRKM8IPL Recombinant
 PRKM8IPL Antibody
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C-Jun-amino-terminal kinase-interacting protein 3

 C-Jun-amino-terminal kinase-interacting protein 3 ELISA Kit
 C-Jun-amino-terminal kinase-interacting protein 3 Recombinant
 C-Jun-amino-terminal kinase-interacting protein 3 Antibody
Also known as C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Mitogen-activated protein kinase 8-interacting protein 3) (Sunday driver 2).
JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. S
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tudies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: axolemma; cytoplasm; dendrite; Golgi membrane; neuron projection; plasma membrane; smooth endoplasmic reticulum

Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling complex scaffold activity

Biological Process: activation of JNK activity; alveolus development; axon guidance; forebrain development; in utero embryonic development; JNK cascade; positive regulation of JNK activity; positive regulation of neuron differentiation; post-embryonic development; protein localization; regulation of gene expression; regulation of JNK cascade; respiratory gaseous exchange; vesicle-mediated transport
 Mapk8ip3 ELISA Kit
 Mapk8ip3 Recombinant
 Mapk8ip3 Antibody
 Jip3 ELISA Kit
 Jip3 Recombinant
 Jip3 Antibody
 Jsap1 ELISA Kit
 Jsap1 Recombinant
 Jsap1 Antibody
 Syd2 ELISA Kit
 Syd2 Recombinant
 Syd2 Antibody
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C-Jun-amino-terminal kinase-interacting protein 4

 C-Jun-amino-terminal kinase-interacting protein 4 ELISA Kit
 C-Jun-amino-terminal kinase-interacting protein 4 Recombinant
 C-Jun-amino-terminal kinase-interacting protein 4 Antibody
Also known as C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1).
JIP4: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific component
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s of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: cytoplasm; cytosol; integral to membrane; microtubule organizing center

Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; protein binding; receptor signaling complex scaffold activity

Biological Process: activation of JNK activity; positive regulation of cell migration; positive regulation of muscle cell differentiation; retrograde transport, endosome to Golgi; spermatogenesis
 SPAG9 ELISA Kit
 SPAG9 Recombinant
 SPAG9 Antibody
 HSS ELISA Kit
 HSS Recombinant
 HSS Antibody
 KIAA0516 ELISA Kit
 KIAA0516 Recombinant
 KIAA0516 Antibody
 MAPK8IP4 ELISA Kit
 MAPK8IP4 Recombinant
 MAPK8IP4 Antibody
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