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Calcium-gated potassium channel

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Calcium-gated potassium channel.

Below are the list of possible Calcium-gated potassium channel products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Calcium-gated potassium channel MthK

 Calcium-gated potassium channel MthK ELISA Kit
 Calcium-gated potassium channel MthK Recombinant
 Calcium-gated potassium channel MthK Antibody
KCNMA1: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a
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key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD). Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both. Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; caveola; cell soma; cytoplasm; dendrite; endoplasmic reticulum; external side of plasma membrane; integral to membrane; mitochondrion; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic active zone membrane; protein complex; terminal button; voltage-gated potassium channel complex

Molecular Function: actin binding; calcium-activated potassium channel activity; large conductance calcium-activated potassium channel activity; potassium channel activity; protein binding; protein complex binding; protein homodimerization activity; voltage-gated potassium channel activity

Biological Process: adult walking behavior; aging; auditory receptor cell differentiation; cell maturation; cellular potassium ion homeostasis; circadian rhythm; eye blink reflex; generation of action potential; locomotor rhythm; micturition; negative regulation of cell volume; neuromuscular process controlling balance; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of vasodilation; potassium ion transport; protein homooligomerization; protein homotetramerization; regulation of aldosterone metabolic process; regulation of membrane potential; regulation of vasodilation; relaxation of vascular smooth muscle; response to calcium ion; response to corticosteroid stimulus; response to estrogen stimulus; response to hypoxia; response to osmotic stress; response to pH; saliva secretion; sensory perception of sound; smooth muscle contraction involved in micturition; synaptic transmission; vasodilation
 mthK ELISA Kit
 mthK Recombinant
 mthK Antibody
 MTH_1520 ELISA Kit
 MTH_1520 Recombinant
 MTH_1520 Antibody
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