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Calcium-responsive transactivator

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Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.

Below are the list of possible Calcium-responsive transactivator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Calcium-responsive transactivator

 Calcium-responsive transactivator ELISA Kit
 Calcium-responsive transactivator Recombinant
 Calcium-responsive transactivator Antibody
Also known as Calcium-responsive transactivator (SS18-like protein 1).
SS18L1: Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor com
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plex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the SS18 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; kinetochore; nuclear body; nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: dendrite development; positive regulation of dendrite morphogenesis; positive regulation of transcription, DNA-dependent; regulation of dendrite development; regulation of transcription, DNA-dependent
 Ss18l1 ELISA Kit
 Ss18l1 Recombinant
 Ss18l1 Antibody
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 Crest Recombinant
 Crest Antibody
 Kiaa0693 ELISA Kit
 Kiaa0693 Recombinant
 Kiaa0693 Antibody
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