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Calsyntenin

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Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).

Below are the list of possible Calsyntenin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Calsyntenin-1

 Calsyntenin-1 ELISA Kit
 Calsyntenin-1 Recombinant
 Calsyntenin-1 Antibody
Also known as Calsyntenin-1 (Alcadein-alpha) (Alc-alpha).
CLSTN1: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP
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fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: cell surface; extracellular region; integral to membrane; postsynaptic density; postsynaptic membrane

Molecular Function: beta-amyloid binding; kinesin binding; X11-like protein binding

Biological Process: positive regulation of synaptic transmission; positive regulation of synaptogenesis; regulation of cell growth
 Clstn1 ELISA Kit
 Clstn1 Recombinant
 Clstn1 Antibody
 Cs1 ELISA Kit
 Cs1 Recombinant
 Cs1 Antibody
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Calsyntenin-2

 Calsyntenin-2 ELISA Kit
 Calsyntenin-2 Recombinant
 Calsyntenin-2 Antibody
Also known as Calsyntenin-2 (Alcadein-gamma) (Alc-gamma).
CLSTN2: May modulate calcium-mediated postsynaptic signals.

Protein type: Inhibitor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q23
 CLSTN2 ELISA Kit
 CLSTN2 Recombinant
 CLSTN2 Antibody
 CS2 ELISA Kit
 CS2 Recombinant
 CS2 Antibody
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Calsyntenin-3

 Calsyntenin-3 ELISA Kit
 Calsyntenin-3 Recombinant
 Calsyntenin-3 Antibody
Also known as Calsyntenin-3 (Alcadein-beta) (Alc-beta).
CLSTN3: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; postsynaptic density; postsynaptic membrane; protein complex

Biological Process: positive regulation of synaptic transmission; pos
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itive regulation of synaptogenesis; regulation of cell growth; synaptic transmission, GABAergic; synaptic transmission, glutamatergic; synaptogenesis
 Clstn3 ELISA Kit
 Clstn3 Recombinant
 Clstn3 Antibody
 Cs3 ELISA Kit
 Cs3 Recombinant
 Cs3 Antibody
 Cstn3 ELISA Kit
 Cstn3 Recombinant
 Cstn3 Antibody
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