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CASP8-associated protein

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Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis.

Below are the list of possible CASP8-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

CASP8-associated protein 2

 CASP8-associated protein 2 ELISA Kit
 CASP8-associated protein 2 Recombinant
 CASP8-associated protein 2 Antibody
Also known as CASP8-associated protein 2 (FLICE-associated huge protein).
CASP8AP2: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a
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TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.

Protein type: Apoptosis; Nuclear receptor co-regulator

Cellular Component: cytoplasm; mitochondrion; nucleus; PML body

Molecular Function: caspase activator activity; identical protein binding; protease binding; protein binding; SUMO polymer binding; transcription corepressor activity

Biological Process: caspase activation; induction of apoptosis via death domain receptors
 Casp8ap2 ELISA Kit
 Casp8ap2 Recombinant
 Casp8ap2 Antibody
 Flash ELISA Kit
 Flash Recombinant
 Flash Antibody
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