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Caspase

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Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.

Below are the list of possible Caspase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Caspase

 Caspase ELISA Kit
 Caspase Recombinant
 Caspase Antibody
Also known as Caspase (drICE).
CASP7: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro

Protein type: Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease

Cellular Component: cytoplasm

Molecular Function: cysteine-type endopeptidase activity

Biological Process: apoptosis; neuron remodeling; nurse cell apoptosis; positive regulation of compound eye retinal cell programmed cell death; programmed cell death; proteolysis; response to X-ray; sali
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vary gland histolysis; spermatid differentiation; sterol regulatory element binding protein cleavage
 Drice ELISA Kit
 Drice Recombinant
 Drice Antibody
 ICE ELISA Kit
 ICE Recombinant
 ICE Antibody
 CG7788 ELISA Kit
 CG7788 Recombinant
 CG7788 Antibody
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Caspase Dronc

 Caspase Dronc ELISA Kit
 Caspase Dronc Recombinant
 Caspase Dronc Antibody
Also known as Caspase Dronc (NEDD2-like caspase).
Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.
 Dronc ELISA Kit
 Dronc Recombinant
 Dronc Antibody
 Nc ELISA Kit
 Nc Recombinant
 Nc Antibody
 CG8091 ELISA Kit
 CG8091 Recombinant
 CG8091 Antibody
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Caspase-1

 Caspase-1 ELISA Kit
 Caspase-1 Recombinant
 Caspase-1 Antibody
CASP7 iso2: Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors

Protein type: Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease

Cellular Component: cytosol; mitochondrion

Mo
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lecular Function: cysteine-type endopeptidase activity; protein binding

Biological Process: actin filament organization; apoptosis; autophagic cell death; cellular response to starvation; cytoplasmic transport, nurse cell to oocyte; multicellular organismal development; neuron remodeling; nurse cell apoptosis; oogenesis; ovarian nurse cell to oocyte transport; positive regulation of autophagy; positive regulation of macroautophagy; programmed cell death; salivary gland cell autophagic cell death
 Dcp-1 ELISA Kit
 Dcp-1 Recombinant
 Dcp-1 Antibody
 CG5370 ELISA Kit
 CG5370 Recombinant
 CG5370 Antibody
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Caspase-10

 Caspase-10 ELISA Kit
 Caspase-10 Recombinant
 Caspase-10 Antibody
Also known as Caspase-10 (CASP-10) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4).
CASP10: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cl
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eaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.63; Protease

Chromosomal Location of Human Ortholog: 2q33-q34

Cellular Component: CD95 death-inducing signaling complex; cytosol

Molecular Function: cysteine-type endopeptidase activity; protein binding; ubiquitin protein ligase binding

Biological Process: apoptosis; cell surface receptor linked signal transduction; induction of apoptosis via death domain receptors; macrophage differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptosis

Disease: Autoimmune Lymphoproliferative Syndrome, Type Iia; Gastric Cancer; Lymphoma, Non-hodgkin, Familial
 CASP10 ELISA Kit
 CASP10 Recombinant
 CASP10 Antibody
 MCH4 ELISA Kit
 MCH4 Recombinant
 MCH4 Antibody
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Caspase-12

 Caspase-12 ELISA Kit
 Caspase-12 Recombinant
 Caspase-12 Antibody
Also known as Caspase-12 (CASP-12).
Involved in the activation cascade of caspases responsible for apoptosis execution.
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Caspase-13

 Caspase-13 ELISA Kit
 Caspase-13 Recombinant
 Caspase-13 Antibody
Also known as Caspase-13 (CASP-13) (Evolutionary related interleukin-1-beta-converting enzyme) (ERICE).
CASP4: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Widely expressed, with highest levels in spleen and lung. Mode
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rate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.64; Protease

Molecular Function: cysteine-type endopeptidase activity

Biological Process: apoptosis; regulation of inflammatory response
 CASP13 ELISA Kit
 CASP13 Recombinant
 CASP13 Antibody
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Caspase-14

 Caspase-14 ELISA Kit
 Caspase-14 Recombinant
 Caspase-14 Antibody
Also known as Caspase-14 (CASP-14).
CASP14: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin. Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. In undifferentiate
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d keratinocytes under postconfluency growth conditions (in vitro). Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum). Expressed in keratinocytes of hair shaft and sebaceous glands. In psoriatic skin only expressed at very low levels. Belongs to the peptidase C14A family.

Protein type: EC 3.4.22.-; Protease

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: cytoplasm; extracellular matrix; nucleus

Molecular Function: cysteine-type endopeptidase activity; protein binding

Biological Process: epidermis development; keratinization
 CASP14 ELISA Kit
 CASP14 Recombinant
 CASP14 Antibody
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Caspase-1-A

 Caspase-1-A ELISA Kit
 Caspase-1-A Recombinant
 Caspase-1-A Antibody
Also known as Caspase-1-A (CASP-1-A) (Interleukin-1 beta convertase homolog A) (xICE-A).
 casp1-a ELISA Kit
 casp1-a Recombinant
 casp1-a Antibody
 casp1a ELISA Kit
 casp1a Recombinant
 casp1a Antibody
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Caspase-1-B

 Caspase-1-B ELISA Kit
 Caspase-1-B Recombinant
 Caspase-1-B Antibody
Also known as Caspase-1-B (CASP-1-B) (Interleukin-1 beta convertase homolog B) (xICE-B).
 casp1-b ELISA Kit
 casp1-b Recombinant
 casp1-b Antibody
 casp1b ELISA Kit
 casp1b Recombinant
 casp1b Antibody
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Caspase-2

 Caspase-2 ELISA Kit
 Caspase-2 Recombinant
 Caspase-2 Antibody
Also known as Caspase-2 (CASP-2) (ICH-1L/1S) (Protease ICH-1).
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival ().
 CASP2 ELISA Kit
 CASP2 Recombinant
 CASP2 Antibody
 ICH1 ELISA Kit
 ICH1 Recombinant
 ICH1 Antibody
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Caspase-3

 Caspase-3 ELISA Kit
 Caspase-3 Recombinant
 Caspase-3 Antibody
Also known as Caspase-3 (CASP-3).
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment d
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omain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage ().
 CASP3 ELISA Kit
 CASP3 Recombinant
 CASP3 Antibody
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Caspase-4

 Caspase-4 ELISA Kit
 Caspase-4 Recombinant
 Caspase-4 Antibody
Also known as Caspase-4 (CASP-4).
Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1
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release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity. Involved in cell death induced by endoplasmic reticulum stress. Activated by direct binding to LPS without the need of an upstream sensor. Does not directly process IL1B.
 CASP4 ELISA Kit
 CASP4 Recombinant
 CASP4 Antibody
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Caspase-5

 Caspase-5 ELISA Kit
 Caspase-5 Recombinant
 Caspase-5 Antibody
Also known as Caspase-5 (CASP-5) (ICE(rel)-III) (Protease ICH-3) (Protease TY).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large
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and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
 CASP5 ELISA Kit
 CASP5 Recombinant
 CASP5 Antibody
 ICH3 ELISA Kit
 ICH3 Recombinant
 ICH3 Antibody
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Caspase-6

 Caspase-6 ELISA Kit
 Caspase-6 Recombinant
 Caspase-6 Antibody
Also known as Caspase-6 (CASP-6).
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death ().
 CASP6 ELISA Kit
 CASP6 Recombinant
 CASP6 Antibody
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Caspase-7

 Caspase-7 ELISA Kit
 Caspase-7 Recombinant
 Caspase-7 Antibody
Also known as Caspase-7 (CASP-7) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residue
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s to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
 CASP7 ELISA Kit
 CASP7 Recombinant
 CASP7 Antibody
 MCH3 ELISA Kit
 MCH3 Recombinant
 MCH3 Antibody
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Caspase-8

 Caspase-8 ELISA Kit
 Caspase-8 Recombinant
 Caspase-8 Antibody
Also known as Caspase-8 (CASP-8).
CASP8: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberat
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ed from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit. Interacts with FADD, CFLAR and PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2. Interacts with human cytomegalovirus/HHV-5 protein vICA/UL36; this interaction inhibits CASP8 activation. Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle. Belongs to the peptidase C14A family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.61; Protease

Cellular Component: CD95 death-inducing signaling complex; cytoplasm; cytosol; lipid raft; microtubule organizing center; mitochondrion; neuron projection; Noc1p-Noc2p complex; nucleoplasm; nucleus; plasma membrane; protein complex

Molecular Function: cysteine-type endopeptidase activity; death receptor binding; endopeptidase activity; identical protein binding; peptidase activity; protein binding; protein complex binding; protein heterodimerization activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding

Biological Process: angiogenesis; apoptosis; caspase activation; heart development; induction of apoptosis via death domain receptors; macrophage differentiation; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis; proteolysis involved in cellular protein catabolic process; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide
 Casp8 ELISA Kit
 Casp8 Recombinant
 Casp8 Antibody
Table BarTOPTable Bar
 

Caspase-9

 Caspase-9 ELISA Kit
 Caspase-9 Recombinant
 Caspase-9 Antibody
Also known as Caspase-9 (CASP-9) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6).
CASP9: a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processin
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g at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms.

Protein type: Apoptosis; EC 3.4.22.62; Protease

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: apoptosome; cytosol

Molecular Function: cysteine-type endopeptidase activity; enzyme activator activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding

Biological Process: apoptosis; caspase activation via cytochrome c; DNA damage response, signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; platelet formation; response to DNA damage stimulus
 CASP9 ELISA Kit
 CASP9 Recombinant
 CASP9 Antibody
 MCH6 ELISA Kit
 MCH6 Recombinant
 MCH6 Antibody
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