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D-2-hydroxyglutarate dehydrogenase

Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.

Below are the list of possible D-2-hydroxyglutarate dehydrogenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

D-2-hydroxyglutarate dehydrogenase

 D-2-hydroxyglutarate dehydrogenase ELISA Kit
 D-2-hydroxyglutarate dehydrogenase Recombinant
 D-2-hydroxyglutarate dehydrogenase Antibody
Also known as D-2-hydroxyglutarate dehydrogenase, mitochondrial.
D2HGDH: an oxidoreductase that act on the CH-OH group of donor with other acceptors. Catalyzes the oxidation of D-2-hydroxyglutarate (2HG) to alpha-ketoglutarate. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. 2 human isoforms produced by alternative splicing. Defects in D2HGDH are the cause of D-2-hydroxyglu
taric aciduria (D2HGA), a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.

Protein type: EC 1.1.99.-; Mitochondrial; Oxidoreductase

Cellular Component: mitochondrion

Molecular Function: (R)-2-hydroxyglutarate dehydrogenase activity; D-lactate dehydrogenase (cytochrome) activity

Biological Process: cellular protein metabolic process; lactate oxidation; response to calcium ion; response to cobalt ion; response to magnesium ion; response to manganese ion; response to zinc ion
 D2hgdh ELISA Kit
 D2hgdh Recombinant
 D2hgdh Antibody
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