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Dachshund

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Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Below are the list of possible Dachshund products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dachshund homolog 1

 Dachshund homolog 1 ELISA Kit
 Dachshund homolog 1 Recombinant
 Dachshund homolog 1 Antibody
Also known as Dachshund homolog 1 (Dach1).
DACH1: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP.
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Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain. Belongs to the DACH/dachshund family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: nucleus; transcription factor complex

Molecular Function: protein binding

Biological Process: multicellular organismal development; negative regulation of cell migration; negative regulation of transcription, DNA-dependent
 DACH1 ELISA Kit
 DACH1 Recombinant
 DACH1 Antibody
 DACH ELISA Kit
 DACH Recombinant
 DACH Antibody
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Dachshund homolog 2

 Dachshund homolog 2 ELISA Kit
 Dachshund homolog 2 Recombinant
 Dachshund homolog 2 Antibody
Also known as Dachshund homolog 2 (Dach2).
DACH2: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 core
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pression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. Belongs to the DACH/dachshund family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Cellular Component: nucleus; transcription factor complex

Biological Process: development of primary female sexual characteristics; regulation of transcription, DNA-dependent
 Dach2 ELISA Kit
 Dach2 Recombinant
 Dach2 Antibody
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