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DCC-interacting protein

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Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.

Below are the list of possible DCC-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DCC-interacting protein 13-alpha

 DCC-interacting protein 13-alpha ELISA Kit
 DCC-interacting protein 13-alpha Recombinant
 DCC-interacting protein 13-alpha Antibody
Also known as DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).
APPL: an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catal
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ytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage.

Protein type: Adaptor/scaffold; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; NuRD complex; vesicle membrane

Molecular Function: identical protein binding; protein binding; protein kinase B binding

Biological Process: cell proliferation; insulin receptor signaling pathway; regulation of glucose import; signal transduction

Disease: Maturity-onset Diabetes Of The Young, Type 14
 APPL1 ELISA Kit
 APPL1 Recombinant
 APPL1 Antibody
 APPL ELISA Kit
 APPL Recombinant
 APPL Antibody
 DIP13A ELISA Kit
 DIP13A Recombinant
 DIP13A Antibody
 KIAA1428 ELISA Kit
 KIAA1428 Recombinant
 KIAA1428 Antibody
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DCC-interacting protein 13-beta

 DCC-interacting protein 13-beta ELISA Kit
 DCC-interacting protein 13-beta Recombinant
 DCC-interacting protein 13-beta Antibody
Also known as DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).
APPL2: a Rab5 effector protein that resides on a subpopulation of endosomes. Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction. Its func
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tion requires Rab5 binding. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. Binds to subunits of the the nucleosome remodeling and deacetylase (NuRD) complex, an abundant and widely expressed deacetylase complex. The NURD complex contains both histone deacetylation and chromatin remodeling ATPase activities. Contains a PH domain and a phosphotyrosine interaction domain (PID) domain that has a structure similar to the insulin receptor substrate-1 PTB domain.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: cytoplasm; endosome membrane; nucleus; NuRD complex

Molecular Function: protein binding

Biological Process: cell proliferation; signal transduction
 APPL2 ELISA Kit
 APPL2 Recombinant
 APPL2 Antibody
 DIP13B ELISA Kit
 DIP13B Recombinant
 DIP13B Antibody
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