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Death-associated protein kinase

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Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3 (By similarity). Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.

Below are the list of possible Death-associated protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Death-associated protein kinase 1

 Death-associated protein kinase 1 ELISA Kit
 Death-associated protein kinase 1 Recombinant
 Death-associated protein kinase 1 Antibody
Also known as Death-associated protein kinase 1 (DAP kinase 1).
DAPK1: a CAMK protein kinase of the Death-associated protein kinase (DAPK) family. Mediates autophagy and is a positive mediator of ER stress-induced and gamma-interferon induced programmed cell death. Catalytic activity is increased by ER stress. Inhibited by autophosphorylation of S308. DAPK -/- cells are protected from ER stress
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-induced cell death, and both apoptosis and autophagy are decreased. Colocalizes with the actin filament system. It is a tumor suppressor candidate, activating p53-dependent apoptosis. Expression is reduced in some cancers, and the promoter is frequently hypermethylated in invasive cancers. Increased expression and mislocalization is seen in epilepsy, where it may regulate neuronal death. A structurally unique serine-threonine kinase that carries eight ankyrin repeats and two putative P-loop consensus sites. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Autophagy; CAMK group; DAPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: actin cytoskeleton; cytoplasm; plasma membrane

Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein binding; protein kinase activity; syntaxin-1 binding

Biological Process: apoptosis; induction of apoptosis via death domain receptors; negative regulation of apoptosis; negative regulation of translation; positive regulation of caspase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation
 Dapk1 ELISA Kit
 Dapk1 Recombinant
 Dapk1 Antibody
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Death-associated protein kinase 2

 Death-associated protein kinase 2 ELISA Kit
 Death-associated protein kinase 2 Recombinant
 Death-associated protein kinase 2 Antibody
Also known as Death-associated protein kinase 2 (DAP kinase 2) (DAP-kinase-related protein 1) (DRP-1).
DAPK2: an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle.
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br>Protein type: CAMK group; DAPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: cytoplasm

Molecular Function: ATP binding; calmodulin binding

Biological Process: anoikis; protein amino acid phosphorylation
 Dapk2 ELISA Kit
 Dapk2 Recombinant
 Dapk2 Antibody
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Death-associated protein kinase 3

 Death-associated protein kinase 3 ELISA Kit
 Death-associated protein kinase 3 Recombinant
 Death-associated protein kinase 3 Antibody
Also known as Death-associated protein kinase 3 (DAP kinase 3) (DAP-like kinase) (Dlk) (MYPT1 kinase) (ZIP-kinase).
calmodulin (CaM)-regulated protein kinase; may be involved in apoptosis and neuronal development [RGD, Feb 2006]
 Dapk3 ELISA Kit
 Dapk3 Recombinant
 Dapk3 Antibody
 Zipk ELISA Kit
 Zipk Recombinant
 Zipk Antibody
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Death-associated protein kinase dapk-1

 Death-associated protein kinase dapk-1 ELISA Kit
 Death-associated protein kinase dapk-1 Recombinant
 Death-associated protein kinase dapk-1 Antibody
Negative regulator of barrier repair and innate immune responses to wounding. Appears to act downstream from or in parallel to muscarinic signaling in the regulation of autophagy.
 dapk-1 ELISA Kit
 dapk-1 Recombinant
 dapk-1 Antibody
 mor-3 ELISA Kit
 mor-3 Recombinant
 mor-3 Antibody
 tag-119 ELISA Kit
 tag-119 Recombinant
 tag-119 Antibody
 K12C11.4 ELISA Kit
 K12C11.4 Recombinant
 K12C11.4 Antibody
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Death-associated protein kinase related

 Death-associated protein kinase related ELISA Kit
 Death-associated protein kinase related Recombinant
 Death-associated protein kinase related Antibody
 Drak ELISA Kit
 Drak Recombinant
 Drak Antibody
 CG32666 ELISA Kit
 CG32666 Recombinant
 CG32666 Antibody
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