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Dedicator of cytokinesis protein

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Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.

Below are the list of possible Dedicator of cytokinesis protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dedicator of cytokinesis protein 1

 Dedicator of cytokinesis protein 1 ELISA Kit
 Dedicator of cytokinesis protein 1 Recombinant
 Dedicator of cytokinesis protein 1 Antibody
Also known as Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).
DOCK1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Interacts with
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the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Belongs to the DOCK family.

Protein type: Adaptor/scaffold; Cytoskeletal; GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding

Biological Process: cell migration; hemopoietic progenitor cell differentiation
 Dock1 ELISA Kit
 Dock1 Recombinant
 Dock1 Antibody
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Dedicator of cytokinesis protein 10

 Dedicator of cytokinesis protein 10 ELISA Kit
 Dedicator of cytokinesis protein 10 Recombinant
 Dedicator of cytokinesis protein 10 Antibody
Also known as Dedicator of cytokinesis protein 10 (Zizimin-3).
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
 DOCK10 ELISA Kit
 DOCK10 Recombinant
 DOCK10 Antibody
 KIAA0694 ELISA Kit
 KIAA0694 Recombinant
 KIAA0694 Antibody
 ZIZ3 ELISA Kit
 ZIZ3 Recombinant
 ZIZ3 Antibody
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Dedicator of cytokinesis protein 11

 Dedicator of cytokinesis protein 11 ELISA Kit
 Dedicator of cytokinesis protein 11 Recombinant
 Dedicator of cytokinesis protein 11 Antibody
Also known as Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2).
DOCK11: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Belongs to the DOCK family.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Molecular Function: Rho GTPase binding; Rho guanyl
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-nucleotide exchange factor activity
 Dock11 ELISA Kit
 Dock11 Recombinant
 Dock11 Antibody
 Ziz2 ELISA Kit
 Ziz2 Recombinant
 Ziz2 Antibody
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Dedicator of cytokinesis protein 2

 Dedicator of cytokinesis protein 2 ELISA Kit
 Dedicator of cytokinesis protein 2 Recombinant
 Dedicator of cytokinesis protein 2 Antibody
DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described.

Protein type: Adaptor/scaffold; GAPs;
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GAPs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytosol; membrane

Molecular Function: protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding

Biological Process: actin cytoskeleton organization and biogenesis; myeloid dendritic cell activation during immune response; positive regulation of phagocytosis; regulation of defense response to virus by virus

Disease: Immunodeficiency 40
 DOCK2 ELISA Kit
 DOCK2 Recombinant
 DOCK2 Antibody
 KIAA0209 ELISA Kit
 KIAA0209 Recombinant
 KIAA0209 Antibody
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Dedicator of cytokinesis protein 3

 Dedicator of cytokinesis protein 3 ELISA Kit
 Dedicator of cytokinesis protein 3 Recombinant
 Dedicator of cytokinesis protein 3 Antibody
Also known as Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP).
DOCK3: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some sm
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all GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9. Belongs to the DOCK family.

Protein type: Cell adhesion; GEFs; GEFs, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: cytoplasm

Molecular Function: protein binding
 DOCK3 ELISA Kit
 DOCK3 Recombinant
 DOCK3 Antibody
 KIAA0299 ELISA Kit
 KIAA0299 Recombinant
 KIAA0299 Antibody
 MOCA ELISA Kit
 MOCA Recombinant
 MOCA Antibody
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Dedicator of cytokinesis protein 4

 Dedicator of cytokinesis protein 4 ELISA Kit
 Dedicator of cytokinesis protein 4 Recombinant
 Dedicator of cytokinesis protein 4 Antibody
DOCK4: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Belongs to the DOCK family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Ras; Motility/polarity/chemotaxis; Oncopro
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tein

Chromosomal Location of Human Ortholog: 7q31.1

Cellular Component: cytosol; membrane; stereocilium; stereocilium bundle

Molecular Function: GTPase activator activity; PDZ domain binding; protein binding; Rac GTPase binding; receptor tyrosine kinase binding
 DOCK4 ELISA Kit
 DOCK4 Recombinant
 DOCK4 Antibody
 KIAA0716 ELISA Kit
 KIAA0716 Recombinant
 KIAA0716 Antibody
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Dedicator of cytokinesis protein 5

 Dedicator of cytokinesis protein 5 ELISA Kit
 Dedicator of cytokinesis protein 5 Recombinant
 Dedicator of cytokinesis protein 5 Antibody
DOCK5: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Belongs to the DOCK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: cytoplasm;
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plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding
 DOCK5 ELISA Kit
 DOCK5 Recombinant
 DOCK5 Antibody
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Dedicator of cytokinesis protein 6

 Dedicator of cytokinesis protein 6 ELISA Kit
 Dedicator of cytokinesis protein 6 Recombinant
 Dedicator of cytokinesis protein 6 Antibody
DOCK6: Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth. Defects in DOCK6 are the cause of Adams-Oliver syndrome type 2 (AOS2). A disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be loca
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ted anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. Belongs to the DOCK family.

Protein type: GEFs; GEFs, misc.; Motility/polarity/chemotaxis

Cellular Component: cytoplasm
 Dock6 ELISA Kit
 Dock6 Recombinant
 Dock6 Antibody
 Kiaa1395 ELISA Kit
 Kiaa1395 Recombinant
 Kiaa1395 Antibody
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Dedicator of cytokinesis protein 7

 Dedicator of cytokinesis protein 7 ELISA Kit
 Dedicator of cytokinesis protein 7 Recombinant
 Dedicator of cytokinesis protein 7 Antibody
DOCK7: a guanine nucleotide exchange factor (GEF) that activates Rac GTPase but not CDC42. Expressed at high levels in the brain and heart. Selectively expressed in the axons and positively regulates axon formation. Knockdown of DOCK7 expression prevents axon formation and overexpression induces formation of multiple axons. Three alternatively-spliced isoforms have been described.

Protein
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type: GEFs; GEFs, misc.

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: axon; focal adhesion; growth cone; neuron projection; signalosome

Molecular Function: Rac GTPase binding

Biological Process: axonogenesis; establishment of neuroblast polarity; interkinetic nuclear migration; microtubule cytoskeleton organization and biogenesis; neurite development; positive regulation of peptidyl-serine phosphorylation; regulation of neurogenesis

Disease: Epileptic Encephalopathy, Early Infantile, 23
 DOCK7 ELISA Kit
 DOCK7 Recombinant
 DOCK7 Antibody
 KIAA1771 ELISA Kit
 KIAA1771 Recombinant
 KIAA1771 Antibody
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Dedicator of cytokinesis protein 8

 Dedicator of cytokinesis protein 8 ELISA Kit
 Dedicator of cytokinesis protein 8 Recombinant
 Dedicator of cytokinesis protein 8 Antibody
DOCK8: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of c
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onnective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, misc.; Motility/polarity/chemotaxis

Cellular Component: leading edge; membrane

Molecular Function: guanyl-nucleotide exchange factor activity

Biological Process: formation of immunological synapse
 Dock8 ELISA Kit
 Dock8 Recombinant
 Dock8 Antibody
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Dedicator of cytokinesis protein 9

 Dedicator of cytokinesis protein 9 ELISA Kit
 Dedicator of cytokinesis protein 9 Recombinant
 Dedicator of cytokinesis protein 9 Antibody
Also known as Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1).
DOCK9: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. Belongs to the DOCK family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho

Cellular Component: cell-cell adherens junction; membrane

Molecular Function: Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
 Dock9 ELISA Kit
 Dock9 Recombinant
 Dock9 Antibody
 D14Wsu89e ELISA Kit
 D14Wsu89e Recombinant
 D14Wsu89e Antibody
 Kiaa1058 ELISA Kit
 Kiaa1058 Recombinant
 Kiaa1058 Antibody
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Proteins Root Name Listing
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