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Delta-actitoxin

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Pore-forming protein that forms cation-selective hydrophilic pores of around 1 nm and causes hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers (By similarity). This protein shows potent hemolytic activity (EC(50)=8.8 ng/ml) that is specifically inhibited by sphingomyelin. Shows no phospholipase A2 activity, nor antimicrobial activity against the four bacteria tested. Is lethal to crayfish (Ref.1).

Below are the list of possible Delta-actitoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DELTA-actitoxin-Aas1a

 DELTA-actitoxin-Aas1a ELISA Kit
 DELTA-actitoxin-Aas1a Recombinant
 DELTA-actitoxin-Aas1a Antibody
Also known as DELTA-actitoxin-Aas1a (DELTA-AITX-Aas1a) (Bandaporin) (Cytolysin bp-1).
Pore-forming protein that forms cation-selective hydrophilic pores of around 1 nm and causes hemolysis. Pore fo
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rmation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers (). This protein shows potent hemolytic activity (EC(50)=8.8 ng/ml) that is specifically inhibited by sphingomyelin. Shows no phospholipase A2 activity, nor antimicrobial activity against the four bacteria tested. Is lethal to crayfish (Ref. 1).
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Delta-actitoxin-Ael1a

 Delta-actitoxin-Ael1a ELISA Kit
 Delta-actitoxin-Ael1a Recombinant
 Delta-actitoxin-Ael1a Antibody
Also known as Delta-actitoxin-Ael1a (Delta-AITX-Ael1a) (APE 2-1) (Anthopleurin-C) (AP-C) (ApC).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during
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signal transduction. It strongly stimulates mammalian cardiac muscle contraction. Paralyzes the shore crab (C.maenas) by tetanic contractions after intramuscular injection.
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Delta-actitoxin-Ael1b

 Delta-actitoxin-Ael1b ELISA Kit
 Delta-actitoxin-Ael1b Recombinant
 Delta-actitoxin-Ael1b Antibody
Also known as Delta-actitoxin-Ael1b (Delta-AITX-Ael1b) (Toxin APE 1-1).
Produces a positive inotropic effect in mammalian heart muscle. Modifies current passing through the fast sodium channel (Nav
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) in neuroblastoma cells, leading to delayed and incomplete inactivation. Paralyzes the shore crab (C.maenas) by tetanic contractions after intramuscular injection.
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Delta-actitoxin-Ael1c

 Delta-actitoxin-Ael1c ELISA Kit
 Delta-actitoxin-Ael1c Recombinant
 Delta-actitoxin-Ael1c Antibody
Also known as Delta-actitoxin-Ael1c (Delta-AITX-Ael1c) (Toxin APE 1-2).
Modifies current passing through the fast sodium channel (Nav) in neuroblastoma cells, leading to delayed and incomplete inac
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tivation. Paralyzes the shore crab (C.maenas) by tetanic contractions after intramuscular injection.
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Delta-actitoxin-Ael1d

 Delta-actitoxin-Ael1d ELISA Kit
 Delta-actitoxin-Ael1d Recombinant
 Delta-actitoxin-Ael1d Antibody
Also known as Delta-actitoxin-Ael1d (Delta-AITX-Ael1d) (Toxin APE 2-2).
Modifies current passing through the fast sodium channel (Nav) in neuroblastoma cells, leading to delayed and incomplete inac
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tivation. Produces a positive inotropic effect in mammalian heart muscle (). Paralyzes the shore crab (C.maenas) by tetanic contractions after intramuscular injection.
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Delta-actitoxin-Ael2d

 Delta-actitoxin-Ael2d ELISA Kit
 Delta-actitoxin-Ael2d Recombinant
 Delta-actitoxin-Ael2d Antibody
Also known as Delta-actitoxin-Ael2d (Delta-AITX-Ael2d) (Toxin APETx3).
Binds to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.
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DELTA-actitoxin-Aeq1a

 DELTA-actitoxin-Aeq1a ELISA Kit
 DELTA-actitoxin-Aeq1a Recombinant
 DELTA-actitoxin-Aeq1a Antibody
Also known as DELTA-actitoxin-Aeq1a (DELTA-AITX-Aeq1a) (Equinatoxin II) (EqT II) (EqTII) (Equinatoxin-2).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and caus
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es cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.
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DELTA-actitoxin-Aeq1b

 DELTA-actitoxin-Aeq1b ELISA Kit
 DELTA-actitoxin-Aeq1b Recombinant
 DELTA-actitoxin-Aeq1b Antibody
Also known as DELTA-actitoxin-Aeq1b (DELTA-AITX-Aeq1b) (Equinatoxin V) (Eqt V) (EqtV) (Equinatoxin-5).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes
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hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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DELTA-actitoxin-Aeq1c

 DELTA-actitoxin-Aeq1c ELISA Kit
 DELTA-actitoxin-Aeq1c Recombinant
 DELTA-actitoxin-Aeq1c Antibody
Also known as DELTA-actitoxin-Aeq1c (DELTA-AITX-Aeq1c) (Equinatoxin IV) (EqT IV) (EqTIV) (Equinatoxin-4).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and caus
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es hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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Delta-actitoxin-Aeq2a

 Delta-actitoxin-Aeq2a ELISA Kit
 Delta-actitoxin-Aeq2a Recombinant
 Delta-actitoxin-Aeq2a Antibody
Also known as Delta-actitoxin-Aeq2a (Delta-AITX-Aeq2a) (Ae1) (Ae1-1) (AeNa) (Neurotoxin 1) (Neurotoxin Ae I).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inact
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ivation during signal transduction (). Causes death to crabs (minimum lethal dose of 25 µg/kg) and mice (PubMed:8835334).
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Delta-actitoxin-Aeq2b 1

 Delta-actitoxin-Aeq2b 1 ELISA Kit
 Delta-actitoxin-Aeq2b 1 Recombinant
 Delta-actitoxin-Aeq2b 1 Antibody
Also known as Delta-actitoxin-Aeq2b 1 (Delta-AITX-Aeq2b 1) (Ae2-1) (Neurotoxin 2-1).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal tra
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nsduction. Causes death to crabs.
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Delta-actitoxin-Aeq2b 2

 Delta-actitoxin-Aeq2b 2 ELISA Kit
 Delta-actitoxin-Aeq2b 2 Recombinant
 Delta-actitoxin-Aeq2b 2 Antibody
Also known as Delta-actitoxin-Aeq2b 2 (Delta-AITX-Aeq2b 2) (Ae2-2) (Neurotoxin 2-2).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal tra
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nsduction. Causes death to crabs.
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Delta-actitoxin-Aeq2b 3

 Delta-actitoxin-Aeq2b 3 ELISA Kit
 Delta-actitoxin-Aeq2b 3 Recombinant
 Delta-actitoxin-Aeq2b 3 Antibody
Also known as Delta-actitoxin-Aeq2b 3 (Delta-AITX-Aeq2b 3) (Ae2-3) (Neurotoxin 2-3).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal tra
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nsduction. Causes death to crabs.
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Delta-actitoxin-Aeq2c

 Delta-actitoxin-Aeq2c ELISA Kit
 Delta-actitoxin-Aeq2c Recombinant
 Delta-actitoxin-Aeq2c Antibody
Also known as Delta-actitoxin-Aeq2c (Delta-AITX-Aeq2c) (Ae3-1) (Neurotoxin 3-1).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transdu
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ction. Causes death to crabs.
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Delta-actitoxin-Aeq2d

 Delta-actitoxin-Aeq2d ELISA Kit
 Delta-actitoxin-Aeq2d Recombinant
 Delta-actitoxin-Aeq2d Antibody
Also known as Delta-actitoxin-Aeq2d (Delta-AITX-Aeq2d) (Ae4-1) (Neurotoxin 4-1).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transdu
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ction. Causes death to crabs.
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Delta-actitoxin-Aer1a

 Delta-actitoxin-Aer1a ELISA Kit
 Delta-actitoxin-Aer1a Recombinant
 Delta-actitoxin-Aer1a Antibody
Also known as Delta-actitoxin-Aer1a (Delta-AITX-Aer1a) (AETX I) (Toxin AETX-1).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduc
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tion.
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DELTA-actitoxin-Afr1a

 DELTA-actitoxin-Afr1a ELISA Kit
 DELTA-actitoxin-Afr1a Recombinant
 DELTA-actitoxin-Afr1a Antibody
Also known as DELTA-actitoxin-Afr1a (DELTA-AITX-Afr1a) (Cytolysin fragaceatoxin C) (fraC).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stim
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ulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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Delta-actitoxin-Afv1a

 Delta-actitoxin-Afv1a ELISA Kit
 Delta-actitoxin-Afv1a Recombinant
 Delta-actitoxin-Afv1a Antibody
Also known as Delta-actitoxin-Afv1a (Delta-AITX-Afv1a) (Toxin AFT-I) (AFI).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin is active on a
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variety of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A).
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Delta-actitoxin-Afv1b

 Delta-actitoxin-Afv1b ELISA Kit
 Delta-actitoxin-Afv1b Recombinant
 Delta-actitoxin-Afv1b Antibody
Also known as Delta-actitoxin-Afv1b (Delta-AITX-Afv1b) (AFT-II) (AFII).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin has a great effica
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cy for Nav1.4/SCN4A (EC(50)=30.62 nM) and Nav1.5/SCN5A (EC(50)=62.5 nM). It is less potent on Nav1.6/SCN8A (EC(50)=about 300 nM), Nav1.1/SCN1A (EC(50)=390.55 nM), Nav1.3/SCN3A (EC(50)=459.36 nM) and Nav1.2/SCN2A (EC(50)=1998.00 nM) (when measured as the increase in the slow component).
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Delta-actitoxin-Amc1a

 Delta-actitoxin-Amc1a ELISA Kit
 Delta-actitoxin-Amc1a Recombinant
 Delta-actitoxin-Amc1a Antibody
Also known as Delta-actitoxin-Amc1a (Delta-AITX-Amc1a) (AnmTX Ama 9a-1) (Peptide toxins Am I) (Peptide toxins Am-1).
May inhibit voltage-gated sodium channels (Nav).
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Delta-actitoxin-Amc2a

 Delta-actitoxin-Amc2a ELISA Kit
 Delta-actitoxin-Amc2a Recombinant
 Delta-actitoxin-Amc2a Antibody
Also known as Delta-actitoxin-Amc2a (Delta-AITX-Amc2a) (Peptide toxin Am II) (Peptide toxin Am-2).
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Delta-actitoxin-Amc3a

 Delta-actitoxin-Amc3a ELISA Kit
 Delta-actitoxin-Amc3a Recombinant
 Delta-actitoxin-Amc3a Antibody
Also known as Delta-actitoxin-Amc3a (Delta-AITX-Amc3a) (Peptide toxin Am III) (Peptide toxin Am-3).
Inhibits voltage-gated sodium channels (Nav).
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Delta-actitoxin-Aspp1a

 Delta-actitoxin-Aspp1a ELISA Kit
 Delta-actitoxin-Aspp1a Recombinant
 Delta-actitoxin-Aspp1a Antibody
Also known as Delta-actitoxin-Aspp1a (Delta-AITX-Aspp1a) (Toxin Hk2a).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduc
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tion (). Has a heart stimulation effect on isolated rat atria that is higher than that of Hk7a, Hk8a and Hk16a (PubMed:12782079,PubMed:14672713).
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Delta-actitoxin-Aspp1b

 Delta-actitoxin-Aspp1b ELISA Kit
 Delta-actitoxin-Aspp1b Recombinant
 Delta-actitoxin-Aspp1b Antibody
Also known as Delta-actitoxin-Aspp1b (Delta-AITX-Aspp1b) (Toxin Hk7a).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction ().
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Has a longer mammalian heart stimulation effect than Hk2a, Hk8a and Hk16a (PubMed:14672713).
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Delta-actitoxin-Aspp1c

 Delta-actitoxin-Aspp1c ELISA Kit
 Delta-actitoxin-Aspp1c Recombinant
 Delta-actitoxin-Aspp1c Antibody
Also known as Delta-actitoxin-Aspp1c (Delta-AITX-Aspp1c) (Toxin Hk8a).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction ().
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Stimulates mammalian heart contraction (PubMed:14672713).
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Delta-actitoxin-Aspp1d

 Delta-actitoxin-Aspp1d ELISA Kit
 Delta-actitoxin-Aspp1d Recombinant
 Delta-actitoxin-Aspp1d Antibody
Also known as Delta-actitoxin-Aspp1d (Delta-AITX-Aspp1d) (Toxin Hk16a).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction ().
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Stimulates mammalian heart contraction (PubMed:14672713).
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DELTA-actitoxin-Ate1a

 DELTA-actitoxin-Ate1a ELISA Kit
 DELTA-actitoxin-Ate1a Recombinant
 DELTA-actitoxin-Ate1a Antibody
Also known as DELTA-actitoxin-Ate1a (DELTA-AITX-Ate1a) (Cytolysin tenebrosin-C).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation an
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d hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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Delta-actitoxin-Avd1a

 Delta-actitoxin-Avd1a ELISA Kit
 Delta-actitoxin-Avd1a Recombinant
 Delta-actitoxin-Avd1a Antibody
Also known as Delta-actitoxin-Avd1a (Delta-AITX-Avd1a) (As1) (Delta-actitoxin-Avd1b) (Delta-AITX-Avd1b) (Toxin ATX-I) (ATX I) (Toxin-1).
Binds specifically to voltage-gated sodium channels (Nav) an
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d delays their inactivation during signal transduction (when tested on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current.
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Delta-actitoxin-Avd1c

 Delta-actitoxin-Avd1c ELISA Kit
 Delta-actitoxin-Avd1c Recombinant
 Delta-actitoxin-Avd1c Antibody
Also known as Delta-actitoxin-Avd1c (Delta-AITX-Avd1c) (ATX-II) (ATX II) (Anemonia sulcata toxin 2) (As2) (Neurotoxin 2) (Toxin II).
Binds specifically to voltage-gated sodium channels (Nav) (site
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3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM) (PubMed:15169781). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured as the increase in the slow component) (PubMed:15169781).
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Delta-actitoxin-Avd1c 1

 Delta-actitoxin-Avd1c 1 ELISA Kit
 Delta-actitoxin-Avd1c 1 Recombinant
 Delta-actitoxin-Avd1c 1 Antibody
Also known as Delta-actitoxin-Avd1c 1 (Delta-AITX-Avd1c 1) (Anemonia viridis toxin 2) (Av2) (Avt 2) (Neurotoxin 2) (Toxin 2c1) (Toxin 2c4) (Toxin Av2-1).
Binds specifically to voltage-gated sodium
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channels (Nav) (site 3), thereby delaying their inactivation during signal transduction. Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A).
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Delta-actitoxin-Avd1c 2

 Delta-actitoxin-Avd1c 2 ELISA Kit
 Delta-actitoxin-Avd1c 2 Recombinant
 Delta-actitoxin-Avd1c 2 Antibody
Also known as Delta-actitoxin-Avd1c 2 (Delta-AITX-Avd1c 2) (Anemonia viridis toxin 2) (Av2) (Avt 2) (Toxin Av2-2).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delayi
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ng their inactivation during signal transduction. Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A).
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Delta-actitoxin-Avd1c 3

 Delta-actitoxin-Avd1c 3 ELISA Kit
 Delta-actitoxin-Avd1c 3 Recombinant
 Delta-actitoxin-Avd1c 3 Antibody
Also known as Delta-actitoxin-Avd1c 3 (Delta-AITX-Avd1c 3) (Anemonia viridis toxin 2) (Av2) (Avt 2) (Toxin Av2-3).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delayi
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ng their inactivation during signal transduction. Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A).
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Delta-actitoxin-Avd1c 4

 Delta-actitoxin-Avd1c 4 ELISA Kit
 Delta-actitoxin-Avd1c 4 Recombinant
 Delta-actitoxin-Avd1c 4 Antibody
Also known as Delta-actitoxin-Avd1c 4 (Delta-AITX-Avd1c 4) (Toxin 2c2) (Toxin 2c3).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during si
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gnal transduction. Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A).
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Delta-actitoxin-Avd1d

 Delta-actitoxin-Avd1d ELISA Kit
 Delta-actitoxin-Avd1d Recombinant
 Delta-actitoxin-Avd1d Antibody
Also known as Delta-actitoxin-Avd1d (Delta-AITX-Avd1d) (ATX-V) (As5) (Toxin V).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduc
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tion. Thus it strongly stimulates mammalian cardiac muscle contraction.
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Delta-actitoxin-Avd1e 1

 Delta-actitoxin-Avd1e 1 ELISA Kit
 Delta-actitoxin-Avd1e 1 Recombinant
 Delta-actitoxin-Avd1e 1 Antibody
Also known as Delta-actitoxin-Avd1e 1 (Delta-AITX-Avd1e 1) (Av2) (Neurotoxin 2) (Toxin 2-4) (Toxin 2c5).
Sodium channel inhibitor. 1 µM completely inhibits voltage-gated sodium channel (Nav) inact
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ivation (PubMed:19609479). Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A) ().
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Delta-actitoxin-Avd1e 2

 Delta-actitoxin-Avd1e 2 ELISA Kit
 Delta-actitoxin-Avd1e 2 Recombinant
 Delta-actitoxin-Avd1e 2 Antibody
Also known as Delta-actitoxin-Avd1e 2 (Delta-AITX-Avd1e 2) (ATX-II) (Av2) (Toxin 2-5).
Sodium channel inhibitor. 1 µM completely inhibits voltage-gated sodium channel (Nav) inactivation (PubMed:19
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609479). Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A) ().
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Delta-actitoxin-Avd1e 3

 Delta-actitoxin-Avd1e 3 ELISA Kit
 Delta-actitoxin-Avd1e 3 Recombinant
 Delta-actitoxin-Avd1e 3 Antibody
Also known as Delta-actitoxin-Avd1e 3 (Delta-AITX-Avd1e 3) (ATX-II) (Av2) (Toxin 2-6).
Sodium channel inhibitor. 1 µM completely inhibits voltage-gated sodium channel (Nav) inactivation (PubMed:19
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609479). Has a strong effect on crustaceans and insects and a weaker effect on mammals. It strongly inhibits D.melanogaster sodium channel (DmNav1). It weakly inhibits the brain sodium channel Nav1.2/SCN2A. It strongly affects the heart sodium channels (Nav1.5/SCN5A) ().
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Delta-actitoxin-Avd1h

 Delta-actitoxin-Avd1h ELISA Kit
 Delta-actitoxin-Avd1h Recombinant
 Delta-actitoxin-Avd1h Antibody
Also known as Delta-actitoxin-Avd1h (Delta-AITX-Avd1h) (Neurotoxin 1-1).
Binds specifically to voltage-gated sodium channels (Nav) and delays their inactivation during signal transduction (when tes
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ted on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current.
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Delta-actitoxin-Avd2a

 Delta-actitoxin-Avd2a ELISA Kit
 Delta-actitoxin-Avd2a Recombinant
 Delta-actitoxin-Avd2a Antibody
Also known as Delta-actitoxin-Avd2a (Delta-AITX-Avd2a) (ATX III) (Av3) (Neurotoxin 3) (Neurotoxin III).
Specific arthropod (crab and insect) toxin that inhibits inactivation of voltage-gated sodium
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channels. It competes well with the site-3 toxin LqhalphaIT (from the scorpion L.quinquestriatus (AC P17728)) on binding to cockroach neuronal membranes (Ki=21.4 nM), and inhibits the inactivation of D.melanogaster channel (DmNav1), but not that of mammalian Navs expressed in Xenopus oocytes. Its activity is synergically enhanced by ligands of receptor site-4 (Bj-xtrIT (AC P56637)). Its ability to inhibit the channel mutant DmNav1[D1701R] only decreases 5-fold, whereas the inhibition activity is completely lost by LqhalphaIT and Av2 when tested on DmNav1[D1701R].
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Delta-actitoxin-Avd2b 1

 Delta-actitoxin-Avd2b 1 ELISA Kit
 Delta-actitoxin-Avd2b 1 Recombinant
 Delta-actitoxin-Avd2b 1 Antibody
Also known as Delta-actitoxin-Avd2b 1 (Delta-AITX-Avd2b 1) (Av7) (Neurotoxin 7).
Voltage-gated sodium channel (Nav) inhibitor. 1 µM completely inhibits insect voltage-gated sodium channel inactiva
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tion (DmNav1 from D.melanogaster).
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Delta-actitoxin-Avd2b 2

 Delta-actitoxin-Avd2b 2 ELISA Kit
 Delta-actitoxin-Avd2b 2 Recombinant
 Delta-actitoxin-Avd2b 2 Antibody
Also known as Delta-actitoxin-Avd2b 2 (Delta-AITX-Avd2b 2) (Av7) (Neurotoxin 7).
Voltage-gated sodium channel (Nav) inhibitor. 1 µM completely inhibits insect voltage-gated sodium channel inactiva
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tion (DmNav1 from D.melanogaster).
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Delta-actitoxin-Avd2b 3

 Delta-actitoxin-Avd2b 3 ELISA Kit
 Delta-actitoxin-Avd2b 3 Recombinant
 Delta-actitoxin-Avd2b 3 Antibody
Also known as Delta-actitoxin-Avd2b 3 (Delta-AITX-Avd2b 3) (Av7) (Neurotoxin 7).
Voltage-gated sodium channel (Nav) inhibitor. 1 µM completely inhibits insect voltage-gated sodium channel inactiva
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tion (DmNav1 from D.melanogaster).
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Delta-actitoxin-Avd2b 4

 Delta-actitoxin-Avd2b 4 ELISA Kit
 Delta-actitoxin-Avd2b 4 Recombinant
 Delta-actitoxin-Avd2b 4 Antibody
Also known as Delta-actitoxin-Avd2b 4 (Delta-AITX-Avd2b 4) (Av7) (Neurotoxin 7).
Voltage-gated sodium channel (Nav) inhibitor. 1 µM completely inhibits insect voltage-gated sodium channel inactiva
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tion (DmNav1 from D.melanogaster).
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Delta-actitoxin-Avd2c

 Delta-actitoxin-Avd2c ELISA Kit
 Delta-actitoxin-Avd2c Recombinant
 Delta-actitoxin-Avd2c Antibody
Also known as Delta-actitoxin-Avd2c (Delta-AITX-Avd2c) (Av10) (Neurotoxin 10).
Sodium channel inhibitor. 5 µM completely inhibits voltage-gated sodium channel (Nav) inactivation.
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Delta-actitoxin-Axm1a

 Delta-actitoxin-Axm1a ELISA Kit
 Delta-actitoxin-Axm1a Recombinant
 Delta-actitoxin-Axm1a Antibody
Also known as Delta-actitoxin-Axm1a (Delta-AITX-Axm1a) (Anthopleurin-A) (AP-A) (ApA) (PCR3-3,4) (Toxin PCR7).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying th
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eir inactivation. This toxin retains the greatest capacity to discriminate between the cardiac (Nav1.5/SCN5A) and neuronal sodium channels (2.5 nM versus 120 nM, when electrophysiologically tested and 14 nM versus 400 nM, when tested by ion flux), whereas its paralog Anthopleurin-B has the highest affinity of all anemone toxins for the mammalian sodium channel (PubMed:13806, PubMed:7612595, PubMed:17092528). Its ability to differentiate between cardiac and skeletal channels appears to be associated with domain 4 of the channel (PubMed:9306007). This toxin does not slow or inhibit closed-state inactivation of cardiac sodium channels, but selectively modifies inactivation from the open-state (PubMed:8576699). It does not display phospholipid-binding activities, suggesting that the domain IV S3-S4 linker is located at the extracellular surface and not buried in the phospholipid bilayer ().
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Delta-actitoxin-Axm1b

 Delta-actitoxin-Axm1b ELISA Kit
 Delta-actitoxin-Axm1b Recombinant
 Delta-actitoxin-Axm1b Antibody
Also known as Delta-actitoxin-Axm1b (Delta-AITX-Axm1b) (Anthopleurin-B) (AP-B) (ApB).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. This t
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oxin has the highest affinity of all anemone toxins for the mammalian sodium channel, whereas its paralog Anthopleurin-A retains the greatest capacity to discriminate between cardiac (Nav1.5/SCN5A) and neuronal sodium channels (PubMed:8916901). When tested electrophysiologically, this toxin exhibits a high affinity for multiple sodium channels with a 50-fold preference for rat cardiac (Nav1.5/SCN5A) over neuronal channels (0.1 nM versus 5 nM). When tested by ion flux, the affinities are similar and appear to have higher affinity (9 nM versus 22 nM) (PubMed:8276803, PubMed:7612595). The residue Lys-37 of this toxin has been shown to interact with channel Nav1.5 (residue Asp-1612 in rat and Asp-1610 in human), which is located in the DIV S3-S4 linker (corresponding to channel site 3) (PubMed:9417050, PubMed:24898004). Selectively modifies sodium channel inactivation from the open state with little effect on channel activation or on inactivation from closed states (). Does not display phospholipid-binding activities, suggesting that the domain IV S3-S4 linker is located at the extracellular surface and not buried in the phospholipid bilayer (PubMed:15632158).
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Delta-actitoxin-Axm1c

 Delta-actitoxin-Axm1c ELISA Kit
 Delta-actitoxin-Axm1c Recombinant
 Delta-actitoxin-Axm1c Antibody
Also known as Delta-actitoxin-Axm1c (Delta-AITX-Axm1c) (PCR1-2) (Toxin PCR1).
Weakly inhibits voltage-gated sodium channels (Nav).
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Delta-actitoxin-Axm1d

 Delta-actitoxin-Axm1d ELISA Kit
 Delta-actitoxin-Axm1d Recombinant
 Delta-actitoxin-Axm1d Antibody
Also known as Delta-actitoxin-Axm1d (Delta-AITX-Axm1d) (PCR2-1) (Toxin PCR3).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transducti
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on. Thus it strongly stimulates mammalian cardiac muscle contraction.
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Delta-actitoxin-Axm1e

 Delta-actitoxin-Axm1e ELISA Kit
 Delta-actitoxin-Axm1e Recombinant
 Delta-actitoxin-Axm1e Antibody
Also known as Delta-actitoxin-Axm1e (Delta-AITX-Axm1e) (PCR2-5) (Toxin PCR2).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin is active on
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a variety of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A).
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Delta-actitoxin-Axm1f

 Delta-actitoxin-Axm1f ELISA Kit
 Delta-actitoxin-Axm1f Recombinant
 Delta-actitoxin-Axm1f Antibody
Also known as Delta-actitoxin-Axm1f (Delta-AITX-Axm1f) (PCR2-10) (Toxin PCR4).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal
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transduction. Thus it may strongly stimulate mammalian cardiac muscle contraction.
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Delta-actitoxin-Axm1g

 Delta-actitoxin-Axm1g ELISA Kit
 Delta-actitoxin-Axm1g Recombinant
 Delta-actitoxin-Axm1g Antibody
Also known as Delta-actitoxin-Axm1g (Delta-AITX-Axm1g) (PCR3-6) (Toxin PCR5).
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Delta-actitoxin-Axm1h

 Delta-actitoxin-Axm1h ELISA Kit
 Delta-actitoxin-Axm1h Recombinant
 Delta-actitoxin-Axm1h Antibody
Also known as Delta-actitoxin-Axm1h (Delta-AITX-Axm1h) (PCR3-7) (Toxin PCR6).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal t
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ransduction. Thus it may strongly stimulate mammalian cardiac muscle contraction.
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Delta-actitoxin-Bcg1a

 Delta-actitoxin-Bcg1a ELISA Kit
 Delta-actitoxin-Bcg1a Recombinant
 Delta-actitoxin-Bcg1a Antibody
Also known as Delta-actitoxin-Bcg1a (Delta-AITX-Bcg1a) (Cangitoxin) (CGTX) (CGX).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transd
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uction. Thus it strongly stimulates mammalian cardiac muscle contraction.
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Delta-actitoxin-Bcg1b

 Delta-actitoxin-Bcg1b ELISA Kit
 Delta-actitoxin-Bcg1b Recombinant
 Delta-actitoxin-Bcg1b Antibody
Also known as Delta-actitoxin-Bcg1b (Delta-AITX-Bcg1b) (Cangitoxin II) (Cangitoxin-2) (Cangitoxin-II) (CGTX-II).
Binds to the sodium channels Nav1.1/SCN1A (EC(50)=165 nM), Nav1.5/SCN5A (EC(50)=103
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nM) and Nav1.6/SCN8A (EC(50)=133 nM), thereby delaying their inactivation (PubMed:18342901, PubMed:21802465). Also inhibits Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.4/SCN4A, but to a lesser extent (PubMed:21802465). Inhibits Nav1.5 differently from isoforms Nav1.1 and Nav1.6. In Nav1.5 the effect consists in a right-shift of inactivation; whereas in both Nav1.1 and Nav1.6 the effect consists in an incomplete inactivation (PubMed:21802465).
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Delta-actitoxin-Bcg1c

 Delta-actitoxin-Bcg1c ELISA Kit
 Delta-actitoxin-Bcg1c Recombinant
 Delta-actitoxin-Bcg1c Antibody
Also known as Delta-actitoxin-Bcg1c (Delta-AITX-Bcg1c) (Cangitoxin III) (Cangitoxin-3) (Cangitoxin-III) (CGTX-III).
Binds specifically to voltage-gated sodium channels SCN1A/Nav1.1, thereby delayin
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g their inactivation during signal transduction.
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Delta-actitoxin-Bcg1d

 Delta-actitoxin-Bcg1d ELISA Kit
 Delta-actitoxin-Bcg1d Recombinant
 Delta-actitoxin-Bcg1d Antibody
Also known as Delta-actitoxin-Bcg1d (Delta-AITX-Bcg1d) (Delta-AITX-Bcg1a) (Delta-AITX-Bcg1b) (Delta-actitoxin-Bcg1e) (Delta-AITX-Bcg1e) (Toxin Bcg 30.24).
Binds to the sodium channels Nav1.1/SCN1A
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(EC(50)=453 nM), Nav1.5/SCN5A (EC(50)=440 nM) and Nav1.6/SCN8A (EC(50)=1740 nM), thereby delaying their inactivation (Ref. 1, PubMed:21802465). Also inhibits Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.4/SCN4A, but to a lesser extent (PubMed:21802465). Toxin effect on Nav1.1 and Nav1.6 (and on Nav1.5, but in a lesser extent) consists in an incomplete inactivation (PubMed:21802465).
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Delta-actitoxin-Bcs1a

 Delta-actitoxin-Bcs1a ELISA Kit
 Delta-actitoxin-Bcs1a Recombinant
 Delta-actitoxin-Bcs1a Antibody
Also known as Delta-actitoxin-Bcs1a (Delta-AITX-Bcs1a) (Bc-III) (Major neurotoxin BcIII).
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Th
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is toxin has moderate activity on Nav1.1/SCN1A (EC(50)=about 300 nM) and Nav1.5/SCN5A (EC(50)=307.00 nM). It less potent on Nav1.4/SCN4A (EC(50)=820.84 nM), Nav1.6/SCN8A (EC(50)=about 900 nM), Nav1.2/SCN2A (EC(50)=1449.17 nM) and Nav1.3/SCN3A (EC(50)=1458.42 nM) (when measured as the increase in the slow component).
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Delta-actitoxin-Bgr2a

 Delta-actitoxin-Bgr2a ELISA Kit
 Delta-actitoxin-Bgr2a Recombinant
 Delta-actitoxin-Bgr2a Antibody
Also known as Delta-actitoxin-Bgr2a (Delta-AITX-Bgr2a) (Bg II) (BgII) (Neurotoxin Bg-2).
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation of the activated
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channels, thereby blocking neuronal transmission. Possess the highest efficacy for the insect sodium channel para/tipE (EC(50)=5.5 nM) (PubMed:12459477), and has effect on Nav1.2/SCN2A (in complex with SCN1B), Nav1.4/SCN4A (in complex with SCN1B) and Nav1.5/SCN5A (in complex with SCN1B) (PubMed:12459477). Also interacts with sodium channels in cardiac cells (PubMed:11704639). Shows lethality to crabs (PubMed:22015268).
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Delta-actitoxin-Bgr2b

 Delta-actitoxin-Bgr2b ELISA Kit
 Delta-actitoxin-Bgr2b Recombinant
 Delta-actitoxin-Bgr2b Antibody
Also known as Delta-actitoxin-Bgr2b (Delta-AITX-Bgr2b) (Bg III) (BgIII) (Neurotoxin Bg-3).
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation of the activate
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d channels, thereby blocking neuronal transmission. Has effect on SCN4A/SCN1B, and SCN5A/SCN1B, has no effect on SCN2A/SCN1B, and SCN10A/SCN1B. Possess the highest efficacy for the insect sodium channel para/tipE. Also interacts with sodium channels in cardiac cells. Shows lethality to crabs (PubMed:22015268).
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Delta-actitoxin-Cgg1a

 Delta-actitoxin-Cgg1a ELISA Kit
 Delta-actitoxin-Cgg1a Recombinant
 Delta-actitoxin-Cgg1a Antibody
Also known as Delta-actitoxin-Cgg1a (Delta-AITX-Cgg1a) (Toxin CgNa).
Slows down the inactivation process of TTX-sensitive voltage-gated sodium channels (Nav). Has a strong crab-paralyzing activity.
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Delta-actitoxin-Cps1a

 Delta-actitoxin-Cps1a ELISA Kit
 Delta-actitoxin-Cps1a Recombinant
 Delta-actitoxin-Cps1a Antibody
Also known as Delta-actitoxin-Cps1a (Delta-AITX-Cps1a) (Cp-1) (Cp I) (CpI).
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation, thereby blocking neuronal tra
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nsmission (). The minimum lethal dose against crabs is 7.3 mg/kg (Ref. 1).
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Delta-actitoxin-Cps1b

 Delta-actitoxin-Cps1b ELISA Kit
 Delta-actitoxin-Cps1b Recombinant
 Delta-actitoxin-Cps1b Antibody
Also known as Delta-actitoxin-Cps1b (Delta-AITX-Cps1b) (Toxin Cp-2) (CpII) (Toxin Cp II).
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation, thereby blockin
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g neuronal transmission (). The minimum lethal dose against crabs is 7.9 mg/kg (Ref. 1).
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Delta-actitoxin-Dar1b

 Delta-actitoxin-Dar1b ELISA Kit
 Delta-actitoxin-Dar1b Recombinant
 Delta-actitoxin-Dar1b Antibody
Also known as Delta-actitoxin-Dar1b (Delta-AITX-Dar1b) (Da II).
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.
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Delta-actitoxin-Eqd1a

 Delta-actitoxin-Eqd1a ELISA Kit
 Delta-actitoxin-Eqd1a Recombinant
 Delta-actitoxin-Eqd1a Antibody
Also known as Delta-actitoxin-Eqd1a (Delta-AITX-Eqd1a) (Delta-actitoxin-Ers1a) (Delta-AITX-Ers1a) (Er-I) (Er I) (Neurotoxin 3 homolog) (Neurotoxin III homolog) (Parasicyonis toxin) (PATX).
Binds sp
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ecifically to sodium channels (Nav) of the axonal membrane of crayfish and prolongs the falling phase of the action potential. It also increases the maximum rates of rise of both action potential and resting potential (PubMed:6107210). Is only active on crustaceans.
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DELTA-actitoxin-Oor1a

 DELTA-actitoxin-Oor1a ELISA Kit
 DELTA-actitoxin-Oor1a Recombinant
 DELTA-actitoxin-Oor1a Antibody
Also known as DELTA-actitoxin-Oor1a (DELTA-AITX-Oor1a) (Actinoporin Or-A) (Cytolysin Or-A).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac sti
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mulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.
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DELTA-actitoxin-Oor1b

 DELTA-actitoxin-Oor1b ELISA Kit
 DELTA-actitoxin-Oor1b Recombinant
 DELTA-actitoxin-Oor1b Antibody
Also known as DELTA-actitoxin-Oor1b (DELTA-AITX-Oor1b) (Actinoporin Or-G) (Cytolysin Or-G).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac sti
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mulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects ().
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DELTA-actitoxin-Ucs1a

 DELTA-actitoxin-Ucs1a ELISA Kit
 DELTA-actitoxin-Ucs1a Recombinant
 DELTA-actitoxin-Ucs1a Antibody
Also known as DELTA-actitoxin-Ucs1a (DELTA-AITX-Ucs1a) (Cytolysin urticinatoxin) (UcI).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes hemolysis. Pore
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formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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Proteins Root Name Listing
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