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Delta-aiptatoxin

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Cardioactive peptide that acts on voltage-gated sodium channels (hNav1.5/SCN5A) and voltage-gated potassium channels (Kv) . Physiologically, this toxin increases the amplitude of cardiomyocyte contraction and slows the late phase of the twitch relaxation velocity with no induction of spontaneous twitching. It increases action potential duration of cardiomyocytes with no effect on its threshold and on the cell resting potential. On insects, it shows neurotoxic activity to the blowfly larvae S.falculaty, causing an immediate spasm that progressed to body contraction and paralysis.

Below are the list of possible Delta-aiptatoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Delta-aiptatoxin-Adi1a

 Delta-aiptatoxin-Adi1a ELISA Kit
 Delta-aiptatoxin-Adi1a Recombinant
 Delta-aiptatoxin-Adi1a Antibody
Also known as Delta-aiptatoxin-Adi1a (Delta-ATTX-Adi1a) (Ion channel modifier Ade-1) (Ade1).
Cardioactive peptide that acts on voltage-gated sodium channels (hNav1.5/SCN5A) and voltage-gated potass
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ium channels (Kv) (PubMed:23356888, PubMed:24749540). The activity on sodium channels consists of inhibition on sodium current inactivation with no significant effect on current activation. This effect may be caused by direct interaction of the toxin with sodium channel site-3 (PubMed:23356888, PubMed:24749540). The activity on potassium channels consists of a significant increase of the amplitude of the transient component of the potassium current, shifting the current threshold to more negative membrane potentials. These effects are concentration-dependent and reversible and may be due to a direct interaction between the toxin and the voltage-sensing domain of the channel (PubMed:24749540). Physiologically, this toxin increases the amplitude of cardiomyocyte contraction and slows the late phase of the twitch relaxation velocity with no induction of spontaneous twitching. It increases action potential duration of cardiomyocytes with no effect on its threshold and on the cell resting potential. On insects, it shows neurotoxic activity to the blowfly larvae S.falculaty, causing an immediate spasm that progressed to body contraction and paralysis.
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DELTA-alicitoxin-Pse1a

 DELTA-alicitoxin-Pse1a ELISA Kit
 DELTA-alicitoxin-Pse1a Recombinant
 DELTA-alicitoxin-Pse1a Antibody
Also known as DELTA-alicitoxin-Pse1a (DELTA-ALTX-Pse1a) (Cytolysin PsTX-20A) (Pstx20) (ptx20a).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes hemolys
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is. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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DELTA-alicitoxin-Pse1b

 DELTA-alicitoxin-Pse1b ELISA Kit
 DELTA-alicitoxin-Pse1b Recombinant
 DELTA-alicitoxin-Pse1b Antibody
Also known as DELTA-alicitoxin-Pse1b (DELTA-ALTX-Pse1b) (Pst-I).
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes hemolysis. Pore formation is a multi-s
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tep process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.
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DELTA-alicitoxin-Pse2a

 DELTA-alicitoxin-Pse2a ELISA Kit
 DELTA-alicitoxin-Pse2a Recombinant
 DELTA-alicitoxin-Pse2a Antibody
Also known as DELTA-alicitoxin-Pse2a (DELTA-ALTX-Pse2a) (Toxin PsTX-60A) (PTX60A).
Causes lethal toxicity to the shrimp Palaemon paucidence, and hemolytic activity toward sheep red blood cells.
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DELTA-alicitoxin-Pse2b

 DELTA-alicitoxin-Pse2b ELISA Kit
 DELTA-alicitoxin-Pse2b Recombinant
 DELTA-alicitoxin-Pse2b Antibody
Also known as DELTA-alicitoxin-Pse2b (DELTA-ALTX-Pse2b) (Toxin PsTX-60B) (PTX60B).
Causes lethal toxicity to the shrimp Palaemon paucidence, and hemolytic activity toward sheep red blood cells.
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